{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:29:34Z","timestamp":1778873374361,"version":"3.51.4"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"16","license":[{"start":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8<jats:sup>+<\/jats:sup>T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents.<\/jats:p>","DOI":"10.1128\/jvi.01464-14","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T01:56:57Z","timestamp":1401933417000},"page":"9472-9475","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Epithelial Immunization Induces Polyfunctional CD8<sup>+<\/sup>T Cells and Optimal Mousepox Protection"],"prefix":"10.1128","volume":"88","author":[{"given":"Adam R.","family":"Hersperger","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"},{"name":"Department of Biology, Albright College, Reading, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"DeHaven","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam E.","family":"Snook","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence C.","family":"Eisenlohr","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.53.1.1","article-title":"The relationship between the virus of infectious ectromelia of mice and vaccinia virus","volume":"53","author":"Burnet FM","year":"1946","unstructured":"BurnetFMBoakeWC. 1946. 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