{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:40:28Z","timestamp":1783107628053,"version":"3.54.6"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"23","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172867 31872450"],"award-info":[{"award-number":["32172867 31872450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2022,12,14]]},"abstract":"<jats:p>The IFN-independent antiviral function of the cGAS-STING pathway has attracted great attention in recent years; however, the nature of this IFN-independent antiviral function is unknown, although STING-induced autophagy has been shown to mediate the STING antiviral activity. First, we analyzed the antiviral activity through the porcine cGAS-pSTING pathway and established that pSTING signaling exerts an IFN-independent antiviral function.<\/jats:p>","DOI":"10.1128\/jvi.01476-22","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T14:00:45Z","timestamp":1668520845000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy"],"prefix":"10.1128","volume":"96","author":[{"given":"Sen","family":"Jiang","sequence":"first","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengwen","family":"Xia","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Luo","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cao","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuening","family":"Wang","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanglong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1909-8760","authenticated-orcid":true,"given":"Nanhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Meurens","sequence":"additional","affiliation":[{"name":"BIOEPAR, INRAE, ONIRIS, Nantes, France"},{"name":"Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-1602","authenticated-orcid":true,"given":"Xiangdong","family":"Li","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-1993","authenticated-orcid":true,"given":"Jianzhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Comparative Medicine Research Institute, Yangzhou University, Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University, Yangzhou, China"},{"name":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/21645515.2014.979640"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00640-08"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07317"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900850106"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1000-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002521"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.040"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244040"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12862"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700699"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413232"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1006-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17156-x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.034"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182192"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202009128"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0251-z"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00947"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167257"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.022"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2021.105143"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104933"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2101212"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1885"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.009"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2100225118"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0244-x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abc4537"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.056"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00037-14"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.098"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.049"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000194"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00613-4"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12306"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8030369"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2022.101206"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716937115"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1535-6108(03)00241-1"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01669"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01476-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01476-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T14:04:49Z","timestamp":1671026689000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01476-22"}},"subtitle":[],"editor":[{"given":"Bryan R. G.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":44,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2022,12,14]]}},"alternative-id":["10.1128\/jvi.01476-22"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01476-22","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"2022-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01476-22"}}