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However, no single bnAb is active against 100% of strains. It is important to gather data on the sensitivity to neutralizing antibodies of all genotypes, especially those more widespread in regions where the prevalence of HIV-1 infection is high. Here, we assembled a large panel of clade CRF02_AG viruses, the most frequent genotype circulating in West Africa and the second most frequent found in several European countries. We evaluated their sensitivities to bnAbs, including those most advanced in clinical trials, and looked for the best combinations. In addition, we observed a trend toward increased resistance to bnAbs over the course of the epidemic.<\/jats:p>","DOI":"10.1128\/jvi.01492-18","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T10:56:29Z","timestamp":1541674589000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02_AG Viruses with a Focus on Evolution over Time"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9686-9194","authenticated-orcid":false,"given":"Karl","family":"Stefic","sequence":"first","affiliation":[{"name":"INSERM U1259, Universit\u00e9 de Tours, Tours, France"},{"name":"Laboratoire de Virologie and CNR VIH-Laboratoire Associ\u00e9, Centre Hospitalier R\u00e9gional Universitaire de Tours, Tours, 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