{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:31:16Z","timestamp":1793320276072,"version":"4.5.0"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"24","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572533"],"award-info":[{"award-number":["31572533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572538"],"award-info":[{"award-number":["31572538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007548","name":"Northwest A and F University","doi-asserted-by":"publisher","award":["Z111021401"],"award-info":[{"award-number":["Z111021401"]}],"id":[{"id":"10.13039\/501100007548","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n            Newcastle disease virus (NDV) substantially impacts the poultry industry worldwide and causes viral encephalitis and neurological disorders leading to brain damage, paralysis, and death. The mechanism of interaction between this neurotropic virus and the avian central nervous system (CNS) is largely unknown. Here, we report that host protein CARD11 presented brain-specific upregulated expression that inhibited NDV replication, which was not due to CARD11-Bcl10-MALT1 (CBM) complex-triggered activation of its downstream signaling pathways. The inhibitory mechanism of viral replication is through the CARD11 CC1 domain, and the viral large polymerase protein (L) competitively interacts with the X domain of the viral phosphoprotein (P), which hampers the P-L interaction, suppressing the viral polymerase activity and viral replication. An\n            <jats:italic>in vivo<\/jats:italic>\n            study indicated that CARD11 alleviated neuropathological lesions and reduced viral replication in chicken brains. These results provide insight into the interaction between NDV infection and the host defense in the CNS and a potential antiviral target for viral neural diseases.\n          <\/jats:p>","DOI":"10.1128\/jvi.01499-19","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T11:36:02Z","timestamp":1569238562000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons"],"prefix":"10.1128","volume":"93","author":[{"given":"Wenbin","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northwest A&amp;F University, Yangling, Shaanxi, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Northwest 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