{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:07:48Z","timestamp":1790215668603,"version":"4.1.0"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"20","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["VR2019-01210"],"award-info":[{"award-number":["VR2019-01210"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["Grant File No. 201607930006"],"award-info":[{"award-number":["Grant File No. 201607930006"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["Grant File No. 201809120016"],"award-info":[{"award-number":["Grant File No. 201809120016"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["Grant File No. 201606525004"],"award-info":[{"award-number":["Grant File No. 201606525004"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN2018\/702"],"award-info":[{"award-number":["CAN2018\/702"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"<jats:p>Human papillomavirus type 16 (HPV16) belongs to the high-risk-group of HPVs and is causing a variety of anogenital cancers and head and neck cancer. The two HPV16 oncoproteins E6 and E7 prevent apoptosis and promote mitosis and are essential for completion of the HPV16 life cycle and for transformation of the infected cell and maintenance of malignancy. E6 and E7 are produced from two mRNAs that are generated in a mutually exclusive manner by alternative splicing. While E6 protein is made from the unspliced mRNA, E7 is made from the spliced version of the same pre-mRNA. Since sufficient quantities of both E6 and E7 are required for malignant transformation, this intricate arrangement of gene expression renders E6 and E7 expression vulnerable to external interference. Since antiviral drugs to HPV16 are not available, a detailed knowledge of the regulation of HPV16 E6 and E7 mRNA splicing may uncover novel targets for therapy.<\/jats:p>","DOI":"10.1128\/jvi.01509-20","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:32:04Z","timestamp":1596724324000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Heterogeneous Nuclear Ribonucleoprotein A1 (hnRNP A1) and hnRNP A2 Inhibit Splicing to Human Papillomavirus 16 Splice Site SA409 through a UAG-Containing Sequence in the E7 Coding Region"],"prefix":"10.1128","volume":"94","author":[{"given":"Yunji","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Shoja Chaghervand","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kajitani","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Gong","sequence":"additional","affiliation":[{"name":"China Institute of Sport and Health Sciences, Beijing Sport University, Beijing, Haidian District, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"},{"name":"The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong Province, China"},{"name":"Institute of Basic Medicine, Shandong First Medical University &amp; Shandong Academy of Medical Sciences, Jinan, Shandong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-0575","authenticated-orcid":false,"given":"Stefan","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02625.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.86"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00152"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.127"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.083"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-38965-8_8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.013"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.026"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.11.014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.035"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.06.006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2984"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.034"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.2741\/3307"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.11.016"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020366"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.7.4691-4699.1996"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.12.9096-9107.1997"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.29-36.1999"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21406"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2608"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky227"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061735"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.9.4249-4263.2006"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.02.023"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2514"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2011.03.003"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.63.3.1441-1447.1989"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-71-5-1243"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10010045"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046412"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-019-00098-0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3062-3070.1999"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.11.7023-7031.1995"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0787-9"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002620107"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00965-16"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt803"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.08.002"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.20.10888-10905.2004"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-007-0174-0"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.03.023"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks984"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140918999"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90477-t"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8085156"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.15.6924"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06369.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-016-0279-9"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.02.001"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25736"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi500180p"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.11.033"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.001"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03434-14"},{"key":"e_1_3_2_59_2","first-page":"7679","article-title":"Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1\/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines","volume":"63","author":"Patry C","year":"2003","unstructured":"Patry C, Bouchard L, Labrecque P, Gendron D, Lemieux B, Toutant J, Lapointe E, Wellinger R, Chabot B. 2003. Small interfering RNA-mediated reduction in heterogeneous nuclear ribonucleoparticule A1\/A2 proteins induces apoptosis in human cancer cells but not in normal mortal cell lines. Cancer Res 63:7679\u20137688.","journal-title":"Cancer Res"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1431"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx606"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.3.2105-2115.2003"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072776"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.6.2739-2752.2002"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01509-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01509-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:01:17Z","timestamp":1646492477000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01509-20"}},"subtitle":[],"editor":[{"given":"Lawrence","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":63,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2020,9,29]]}},"alternative-id":["10.1128\/JVI.01509-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01509-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"assertion":[{"value":"2020-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01509-20"}}