{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:03:36Z","timestamp":1794006216358,"version":"4.8.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"ANR","award":["ANR-11-INBS-0008"],"award-info":[{"award-number":["ANR-11-INBS-0008"]}]},{"name":"ANR","award":["ANR-10-EQPX-02-01"],"award-info":[{"award-number":["ANR-10-EQPX-02-01"]}]},{"name":"Innovative Medicines Initiative Joint Undertaking","award":["n.115308"],"award-info":[{"award-number":["n.115308"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              The non-human primate (NHP) model (specifically rhesus and cynomolgus macaques) has facilitated our understanding of the pathogenic mechanisms of yellow fever (YF) disease and allowed the evaluation of the safety and efficacy of YF-17D vaccines. However, the accuracy of this model in mimicking vaccine-induced immunity in humans remains to be fully determined. We used a systems biology approach to compare hematological, biochemical, transcriptomic, and innate and antibody-mediated immune responses in cynomolgus macaques and human participants following YF-17D vaccination. Immune response progression in cynomolgus macaques followed a similar course as in adult humans but with a slightly earlier onset. Yellow fever virus neutralizing antibody responses occurred earlier in cynomolgus macaques [by Day 7[(D7)], but titers &gt; 10 were reached in both species by D14 post-vaccination and were not significantly different by D28 [plaque reduction neutralization assay (PRNT)\n              <jats:sub>50<\/jats:sub>\n              titers 3.6 Log vs 3.5 Log in cynomolgus macaques and human participants, respectively;\n              <jats:italic>P<\/jats:italic>\n              = 0.821]. Changes in neutrophils, NK cells, monocytes, and T- and B-cell frequencies were higher in cynomolgus macaques and persisted for 4 weeks versus less than 2 weeks in humans. Low levels of systemic inflammatory cytokines (IL-1RA, IL-8, MIP-1\u03b1, IP-10, MCP-1, or VEGF) were detected in either or both species but with no or only slight changes versus baseline. Similar changes in gene expression profiles were elicited in both species. These included enriched and up-regulated type I IFN-associated viral sensing, antiviral innate response, and dendritic cell activation pathways D3\u2013D7 post-vaccination in both species. Hematological and blood biochemical parameters remained relatively unchanged versus baseline in both species. Low-level YF-17D viremia (RNAemia) was transiently detected in some cynomolgus macaques [28% (5\/18)] but generally absent in humans [except one participant (5%; 1\/20)].\n            <\/jats:p>\n            <jats:sec>\n              <jats:title>IMPORTANCE<\/jats:title>\n              <jats:p>Cynomolgus macaques were confirmed as a valid surrogate model for replicating YF-17D vaccine-induced responses in humans and suggest a key role for type I IFN.<\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/jvi.01516-23","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:00:46Z","timestamp":1712149246000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Cynomolgus macaques as a translational model of human immune responses to yellow fever 17D vaccination"],"prefix":"10.1128","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8984-3183","authenticated-orcid":true,"given":"Nathalie","family":"Mantel","sequence":"first","affiliation":[{"name":"Research and Development, Sanofi, Marcy L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Piras-Douce","sequence":"additional","affiliation":[{"name":"Research and Development, Sanofi, Marcy L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Chautard","sequence":"additional","affiliation":[{"name":"Research and Development, Sanofi, Marcy L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Marcos-Lopez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB\/IDMIT), Fontenay aux Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L.","family":"Bodinham","sequence":"additional","affiliation":[{"name":"Surrey Clinical Research Centre, University of Surrey, Guildford, Surrey, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cosma","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB\/IDMIT), Fontenay aux Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Courtois","sequence":"additional","affiliation":[{"name":"Research and Development, Sanofi, Marcy L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Dhooge","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB\/IDMIT), Fontenay aux Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylviane","family":"Gautheron","sequence":"additional","affiliation":[{"name":"Research and Development, Sanofi, Marcy L'Etoile, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan H. E.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Infection Biology, Berlin, Germany; Max Planck Institute for Multidisciplinary Sciences, G\u00f6ttingen, Germany"},{"name":"Hagler Institute for Advanced Study, Texas A&amp;M University, College Station, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Pizzoferro","sequence":"additional","affiliation":[{"name":"Surrey Clinical Research Centre, University of Surrey, Guildford, Surrey, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J. 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