{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:25:46Z","timestamp":1759742746606,"version":"3.41.2"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-AI133673"],"award-info":[{"award-number":["RO1-AI133673"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["WT104748MA"],"award-info":[{"award-number":["WT104748MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2022,1,26]]},"abstract":"<jats:p>Very early initiation of antiretroviral therapy (ART) in pediatric HIV infection offers a unique opportunity to limit the size and diversity of the viral reservoir. However, only rarely is ART alone sufficient to achieve remission.<\/jats:p>","DOI":"10.1128\/jvi.01535-21","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T19:16:10Z","timestamp":1636571770000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Two Distinct Mechanisms Leading to Loss of Virological Control in the Rare Group of Antiretroviral Therapy-Naive, Transiently Aviremic Children Living with HIV"],"prefix":"10.1128","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-0424","authenticated-orcid":true,"given":"Vinicius A.","family":"Vieira","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Adland","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas E.","family":"Grayson","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Csala","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa\u2019eeda","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kimberley Hospital, Kimberley, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherrelle","family":"Dacon","sequence":"additional","affiliation":[{"name":"Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohin","family":"Athavale","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Han","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Muenchhoff","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer Institute &amp; Gene Center, Virology, National Reference Center for Retroviruses, LMU M\u00fcnchen, Munich, Germany"},{"name":"German Center for Infection Research, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-0550","authenticated-orcid":true,"given":"David","family":"Bonsall","sequence":"additional","affiliation":[{"name":"Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"},{"name":"Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Jooste","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Kimberley Hospital, Kimberley, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J. R.","family":"Goulder","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"},{"name":"HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117601"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu432"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax7350"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.19"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302976"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00232-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08311-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100344"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.100241"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/605446"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029717"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.7.4650-4655.1994"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.9.6103-6110.1994"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2035"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10237"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8825"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98463"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4049\/jimmunol.154.1.433","article-title":"HIV-1-specific cytotoxic T lymphocyte responses in the first year of life","volume":"154","author":"Luzuriaga K","year":"1995","unstructured":"Luzuriaga K, Holmes D, Hereema A, Wong J, Panicali DL, Sullivan JL. 1995. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. J Immunol 154:433\u2013443.","journal-title":"J Immunol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00624-07"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901481"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3277"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004954"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1048"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199704150-00008"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.054"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.038"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002043"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20162123"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195271"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/526786"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001443"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni845"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.12.009"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611244104"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070784"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-4818"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.08.010"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03113"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00320-10"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131591"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00539-12"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12529"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12528"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06728-11"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.11.8103"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0149-5"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-016-0300-y"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003078"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.12.6889-6898.2003"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.005"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.022"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00921-09"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00382-20"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-13-104"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01535-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01535-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T21:36:27Z","timestamp":1673732187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01535-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,26]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1,26]]}},"alternative-id":["10.1128\/JVI.01535-21"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01535-21","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"type":"print","value":"0022-538X"},{"type":"electronic","value":"1098-5514"}],"subject":[],"published":{"date-parts":[[2022,1,26]]},"assertion":[{"value":"2021-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01535-21"}}