{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:26:21Z","timestamp":1792520781022,"version":"4.5.0"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal models have shown that vaccination with formalin-inactivated RSV (FI-RSV) leads to prominent airway eosinophilic inflammation following RSV challenge; however, the roles of pulmonary eosinophilia in the antiviral response and in disease pathogenesis are inadequately understood.\n                    <jats:italic>In vivo<\/jats:italic>\n                    studies in mice with eotaxin and\/or interleukin 5 (IL-5) deficiency showed that FI-RSV vaccination did not lead to enhanced pulmonary disease, where following challenge there were reduced pulmonary eosinophilia, inflammation, Th2-type cytokine responses, and altered chemokine (TARC and CCL17) responses. In contrast to wild-type mice, RSV was recovered at high titers from the lungs of eotaxin- and\/or IL-5-deficient mice. Adoptive transfer of eosinophils to FI-RSV-immunized eotaxin- and IL-5-deficient (double-deficient) mice challenged with RSV was associated with potent viral clearance that was mediated at least partly through nitric oxide. These studies show that pulmonary eosinophilia has dual outcomes: one linked to RSV-induced airway inflammation and pulmonary pathology and one with innate features that contribute to a reduction in the viral load.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>IMPORTANCE<\/jats:bold>\n                    This study is critical to understanding the mechanisms attributable to RSV vaccine-enhanced disease. This study addresses the hypothesis that IL-5 and eotaxin are critical in pulmonary eosinophil response related to FI-RSV vaccine-enhanced disease. The findings suggest that in addition to mediating tissue pathology, eosinophils within a Th2 environment also have antiviral activity.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01536-14","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T02:32:20Z","timestamp":1416450740000},"page":"1564-1578","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Dual Proinflammatory and Antiviral Properties of Pulmonary Eosinophils in Respiratory Syncytial Virus Vaccine-Enhanced Disease"],"prefix":"10.1128","volume":"89","author":[{"given":"Yung-Chang","family":"Su","sequence":"first","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"},{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dijana","family":"Townsend","sequence":"additional","affiliation":[{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"},{"name":"Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara J.","family":"Herrero","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"},{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Zaid","sequence":"additional","affiliation":[{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Rolph","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"},{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle E.","family":"Gahan","sequence":"additional","affiliation":[{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny A.","family":"Rudd","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus I.","family":"Matthaei","sequence":"additional","affiliation":[{"name":"Department of Translational Biosciences, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Foster","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Asthma and Respiratory Disease, Faculty of Health and Medicine and Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Dent","sequence":"additional","affiliation":[{"name":"School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A.","family":"Tripp","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubov","family":"Simson","sequence":"additional","affiliation":[{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia"},{"name":"Faculty of Education, Science, Technology and Mathematics, University of Canberra, Canberra, ACT, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00003-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085367"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00142-X"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/rr184"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.15.1440"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.08.031"},{"key":"e_1_3_2_9_2","first-page":"536","article-title":"Respiratory virus vaccines. I. Respiratory syncytial and parainfluenza virus vaccines","volume":"93","author":"Potash L","year":"1966","unstructured":"Potash L, Tytell AA, Sweet BH, Machlowitz RA, Stokes J Jr, Weibel RE, Woodhour AF, Hilleman MR. 1966. Respiratory virus vaccines. I. Respiratory syncytial and parainfluenza virus vaccines. Am Rev Respir Dis 93:536\u2013548.","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120954"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120955"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.5.428"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-071340"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2376"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.8.5321-5325.1994"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.12.7444-7451.1992"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(97)00218-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.10.8485-8495.1999"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907621"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.18.9831-9844.2003"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.14.6873-6881.2002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.4.785"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80294-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00017-7"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.5.1425"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118600"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/315783"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.04.049"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020009"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12655"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5595"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.042"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2600"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.08.010"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02595.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.160.5.2393","article-title":"IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL\/6)","volume":"160","author":"Huffnagle GB","year":"1998","unstructured":"Huffnagle GB, Boyd MB, Street NE, Lipscomb MF. 1998. IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL\/6). J Immunol 160:2393\u20132400.","journal-title":"J Immunol"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2686"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70069-2"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(94)90002-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.031"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00496-06"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1648"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2437"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.2205"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.4.4360"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.24.12421-12430.2001"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2142"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.4.2050-2057.2005"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119234"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9702074"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568010033484214"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.16.8753-8760.2004"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024037"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.2982"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.195"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.207"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1490OC"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.6.1489"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0394OC"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20091"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.23.5327"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1086\/515322"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.04.005"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-200246"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80592-X"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9805083"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91152-7"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105712"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.1911"},{"key":"e_1_3_2_70_2","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.4049\/jimmunol.160.10.4889","article-title":"Respiratory syncytial virus-infected pulmonary epithelial cells induce eosinophil degranulation by a CD18-mediated mechanism","volume":"160","author":"Olszewska-Pazdrak B","year":"1998","unstructured":"Olszewska-Pazdrak B, Pazdrak K, Ogra PL, Garofalo RP. 1998. Respiratory syncytial virus-infected pulmonary epithelial cells induce eosinophil degranulation by a CD18-mediated mechanism. J Immunol 160:4889\u20134895.","journal-title":"J Immunol"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-502443"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01536-14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01536-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T05:44:08Z","timestamp":1689659048000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01536-14"}},"subtitle":[],"editor":[{"given":"T. S.","family":"Dermody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1128\/JVI.01536-14"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01536-14","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725242627.793566522","asserted-by":"object"}]},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"2014-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}