{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:28:32Z","timestamp":1780824512920,"version":"3.54.1"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","doi-asserted-by":"crossref","award":["2015ZX09102025"],"award-info":[{"award-number":["2015ZX09102025"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Major Project of the Ministru of Science and Technology of China","award":["2015ZX09102024"],"award-info":[{"award-number":["2015ZX09102024"]}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project of the Ministry of Science and Technology of China","doi-asserted-by":"crossref","award":["2016ZX10004222"],"award-info":[{"award-number":["2016ZX10004222"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China Cooperation and Exchange Program","award":["816110193"],"award-info":[{"award-number":["816110193"]}]},{"name":"NSFC Innovative Research Group","award":["81621091"],"award-info":[{"award-number":["81621091"]}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI109762-1"],"award-info":[{"award-number":["U19AI109762-1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2017122"],"award-info":[{"award-number":["2017122"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","award":["IER-143487"],"award-info":[{"award-number":["IER-143487"]}],"id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n            EBOV is one of the deadliest viruses to humans. It has been over 40\u2009years since EBOV was first reported, but no cure is available. Research breakthroughs over the past 5\u2009years have shown that MAbs constitute an effective therapy for EBOV infections. However, MAbs are expensive and difficult to produce in large amounts and therefore may only play a limited role during an epidemic. A cheaper alternative is required, especially since EBOV is endemic in several third world countries with limited medical resources. Here, we used a standard protocol to produce large amounts of antiserum F(ab\u2032)\n            <jats:sub>2<\/jats:sub>\n            fragments from horses vaccinated with an EBOV vaccine, and we tested the protectiveness in monkeys. We showed that F(ab\u2032)\n            <jats:sub>2<\/jats:sub>\n            was effective in 100% of monkeys even after the animals were visibly ill with EBOV disease. Thus, F(ab\u2032)\n            <jats:sub>2<\/jats:sub>\n            could be a very good option for large-scale treatments of patients and should be advanced to clinical testing.\n          <\/jats:p>","DOI":"10.1128\/jvi.01548-18","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T10:07:14Z","timestamp":1544695634000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Equine-Origin Immunoglobulin Fragments Protect Nonhuman Primates from Ebola Virus Disease"],"prefix":"10.1128","volume":"93","author":[{"given":"Hualei","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China"},{"name":"Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhai","family":"Bi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keding","family":"Cheng","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengguo","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Gai","sequence":"additional","affiliation":[{"name":"Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 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Ltd., Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zou","sequence":"additional","affiliation":[{"name":"Changchun Institute of Biological Products Co. 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Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies. MMWR Recomm Rep 59(RR-2):1\u20139. www.cdc.gov\/mmwr\/pdf\/rr\/rr5902.pdf.","journal-title":"MMWR Recomm Rep"},{"key":"e_1_3_2_20_2","unstructured":"Centers for Disease Control and Prevention. 2015. Tetanus. www.cdc.gov\/vaccines\/pubs\/pinkbook\/tetanus.html. Accessed 25 May 2018."},{"key":"e_1_3_2_21_2","first-page":"271","article-title":"Ebola haemorrhagic fever in Zaire, 1976: report of an international commission","volume":"56","author":"World Health Organization","year":"1978","unstructured":"World Health Organization. 1978. Ebola haemorrhagic fever in Zaire, 1976: report of an international commission. 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(In Russian.)","journal-title":"Vopr Virusol"},{"key":"e_1_3_2_26_2","first-page":"253","article-title":"Animal models of Ebolavirus infection","volume":"67","author":"St Claire MC","year":"2017","unstructured":"St Claire MC, Ragland DR, Bollinger L, Jahrling PB. 2017. Animal models of Ebolavirus infection. Comp Med 67:253\u2013262.","journal-title":"Comp Med"},{"key":"e_1_3_2_27_2","first-page":"135","article-title":"Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses","volume":"11","author":"Jahrling PB","year":"1996","unstructured":"Jahrling PB, Geisbert J, Swearengen JR, Jaax GP, Lewis T, Huggins JW, Schmidt JJ, LeDuc JW, Peters CJ. 1996. Passive immunization of Ebola virus-infected cynomolgus monkeys with immunoglobulin from hyperimmune horses. 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