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In particular, Jun\u00edn mammarenavirus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. At present, little is known about the cellular proteins that the arenavirus matrix protein (Z) hijacks to accomplish its various functions, including driving the process of virus release. Furthermore, there is little knowledge regarding host proteins incorporated into arenavirus particles and their importance for virion function. To address these deficiencies, we used mass spectrometry to identify human proteins that (i) interact with the JUNV matrix protein inside cells or within virus-like particles (VLPs) and\/or (ii) are incorporated into\n            <jats:italic>bona fide<\/jats:italic>\n            JUNV strain Candid#1 particles. Bioinformatics analyses revealed that multiple classes of human proteins were overrepresented in the data sets, including ribosomal proteins, Ras superfamily proteins, and endosomal sorting complex required for transport (ESCRT) proteins. Several of these proteins were required for the propagation of JUNV (ADP ribosylation factor 1 [ARF1], ATPase, H\n            <jats:sup>+<\/jats:sup>\n            transporting, lysosomal 38-kDa, V0 subunit d1 [ATP6V0D1], and peroxiredoxin 3 [PRDX3]), lymphocytic choriomeningitis mammarenavirus (LCMV) (Rab5c), or both viruses (ATP synthase, H\n            <jats:sup>+<\/jats:sup>\n            transporting, mitochondrial F1 complex, beta polypeptide [ATP5B] and IMP dehydrogenase 2 [IMPDH2]). Furthermore, we show that the release of infectious JUNV particles, but not LCMV particles, requires a functional ESCRT pathway and that ATP5B and IMPDH2 are required for JUNV budding. In summary, we have provided a large-scale map of host machinery that associates with JUNV and identified key human proteins required for its propagation. This data set provides a resource for the field to guide antiviral target discovery and to better understand the biology of the arenavirus matrix protein and the importance of host proteins for virion function.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            Arenaviruses are deadly human pathogens for which there are no U.S. Food and Drug Administration-approved vaccines and only limited treatment options. Little is known about the host proteins that are incorporated into arenavirus particles or that associate with its multifunctional matrix protein. Using Jun\u00edn mammarenavirus (JUNV), the causative agent of Argentine hemorrhagic fever, as a model organism, we mapped the human proteins that are incorporated into JUNV particles or that associate with the JUNV matrix protein. Functional analysis revealed host machinery that is required for JUNV propagation, including the cellular ESCRT pathway. This study improves our understanding of critical arenavirus-host interactions and provides a data set that will guide future studies to better understand arenavirus pathogenesis and identify novel host proteins that can be therapeutically targeted.\n          <\/jats:p>","DOI":"10.1128\/jvi.01565-17","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T16:11:39Z","timestamp":1511971899000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["A Proteomics Survey of Jun\u00edn Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication"],"prefix":"10.1128","volume":"92","author":[{"given":"Christopher M.","family":"Ziegler","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"},{"name":"Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Eisenhauer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie A.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loan N.","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedran","family":"Beganovic","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-3961","authenticated-orcid":false,"given":"Benjamin R.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"},{"name":"Cellular, Molecular, and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Shirley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion E.","family":"Weir","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan A.","family":"Ballif","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Botten","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, Vermont, USA"},{"name":"Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"25","article-title":"Mammalian reservoirs of arenaviruses","volume":"262","author":"Salazar-Bravo J","year":"2002","unstructured":"Salazar-Bravo J, Ruedas LA, Yates TL. 2002. 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