{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:20:40Z","timestamp":1771982440751,"version":"3.50.1"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Infectious Disease Institute, Ohio State University","award":["5T32Al112542"],"award-info":[{"award-number":["5T32Al112542"]}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P01 Al112524"],"award-info":[{"award-number":["P01 Al112524"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008747","name":"OSU | Center for Clinical and Translational Science, Ohio State University","doi-asserted-by":"publisher","award":["5TL1TR002735"],"award-info":[{"award-number":["5TL1TR002735"]}],"id":[{"id":"10.13039\/100008747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2021,1,13]]},"abstract":"<jats:p>Globally, respiratory syncytial virus (RSV) is a major cause of death in children under 1 year of age, yet no vaccine is available. We have generated a novel RSV live attenuated vaccine candidate containing mutations in the L and G proteins.<\/jats:p>","DOI":"10.1128\/jvi.01568-20","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T14:12:59Z","timestamp":1605190379000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque"],"prefix":"10.1128","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-243X","authenticated-orcid":false,"given":"Tiffany","family":"Jenkins","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA"},{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongzhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaoge","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phylip","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Corry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Walker","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuncion","family":"Mejias","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Ramilo","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Niewiesk","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-317X","authenticated-orcid":false,"given":"Mark E.","family":"Peeples","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1986.02140200053026"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-199706000-00010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.13.3.371-384.2000"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000133165.85909.08"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.6.937"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120955"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120954"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-38919-1_4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.2.10.955-961.1968"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077104"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz408"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy040"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy066"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-06099-5_3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13373-13384.2005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.018"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1979"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09489"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03420-13"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509821103"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00986-09"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02351-15"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.11.5654-5666.2002"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2009.02.017"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3687-8_15"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040206618770518"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-12-2881"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.3.1189"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(10)73004-5"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2377"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00876-14"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01095-14"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2018.02.022"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-CM-19-000107"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-38919-1_13"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-38919-1_4"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz603"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac8463"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00630-08"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00566"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.15.8426-8439.2003"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-861-7:183"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.22.10508-10513.2000"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-3-479"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-11-2953"},{"key":"e_1_3_2_49_2","first-page":"31","article-title":"Characterization of cotton rat (Sigmodon hispidus) eosinophils, including their response to respiratory syncytial virus infection","volume":"68","author":"Green MG","year":"2018","unstructured":"Green MG, Petroff N, la Perle KMD, Niewiesk S. 2018. Characterization of cotton rat (Sigmodon hispidus) eosinophils, including their response to respiratory syncytial virus infection. Comp Med 68:31\u201340.","journal-title":"Comp Med"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix489"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.05.088"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02180-16"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01568-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01568-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:06:44Z","timestamp":1646492804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01568-20"}},"subtitle":[],"editor":[{"given":"Kanta","family":"Subbarao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,1,13]]}},"alternative-id":["10.1128\/JVI.01568-20"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01568-20","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,13]]},"assertion":[{"value":"2020-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01568-20"}}