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This disease can occur after reactivation of herpes simplex virus 1 in the trigeminal ganglia, leading to dissemination of virus to, and infection of, the cornea. A clinical paradox is evidenced by the bilateral presence of latent viral genomes in both trigeminal ganglia, while for any given patient the disease is unilateral with recurrences in a single eye. Our study links the kinetics of early infection to unilateral disease phenomenon and demonstrates protection against viral reactivation when kinetics are exploited. Our results have direct implications in the understanding of human disease pathogenesis and immunotherapeutic strategies for the treatment of HK and viral reactivations.<\/jats:p>","DOI":"10.1128\/jvi.01586-19","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T11:50:20Z","timestamp":1569498620000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Herpes Simplex Virus 1 Replication, Ocular Disease, and Reactivations from Latency Are Restricted Unilaterally after Inoculation of Virus into the Lip"],"prefix":"10.1128","volume":"93","author":[{"given":"Nolwenn","family":"Poccardi","sequence":"first","affiliation":[{"name":"Institut de Biologie Int\u00e9grative de la Cellule (I2BC), D\u00e9partement de Virologie, CNRS, Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Institut de Biologie Int\u00e9grative de la Cellule (I2BC), D\u00e9partement de Virologie, CNRS, Gif-sur-Yvette, France"},{"name":"CEA-Universit\u00e9 Paris Sud, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IDMIT departement, IBFJ, Fontenay-aux-Roses, France"},{"name":"Universit\u00e9 Paris Sud, Centre Hospitalier Universitaire de Bic\u00eatre, Service d\u2019Ophtalmologie, APHP, DHU Vision &amp; 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