{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:50:56Z","timestamp":1790110256186,"version":"4.0.1"},"reference-count":98,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIH Intramural Research Program","award":["ZIASC010357-17"],"award-info":[{"award-number":["ZIASC010357-17"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:p>Epstein-Barr virus represents an important human pathogen with an etiological role in the development of several cancers. By elucidation of a genome-wide polyadenylation landscape of EBV in JSC-1, Raji, and Akata cells, we have redefined the EBV transcriptome and mapped individual polymerase II (Pol II) transcripts of viral genes to each one of the mapped pA sites at single-nucleotide resolution as well as the depth of expression. By unveiling a new class of viral lytic RNA transcripts antisense to latent EBNAs, we provide a novel mechanism of how EBV might control the expression of viral latent genes and lytic infection. Thus, this report takes another step closer to understanding EBV gene structure and expression and paves a new path for antiviral approaches.<\/jats:p>","DOI":"10.1128\/jvi.01593-18","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T10:29:54Z","timestamp":1540376994000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["A Genome-Wide Epstein-Barr Virus Polyadenylation Map and Its Antisense RNA to EBNA"],"prefix":"10.1128","volume":"93","author":[{"given":"Vladimir","family":"Majerciak","sequence":"first","affiliation":[{"name":"Tumor Virus RNA Biology Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Tumor Virus RNA Biology Section, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80622-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008173430707"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.82"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.84"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004656"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.61.11.3424-3430.1987"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07398.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.491167"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01606-13"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01046-17"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22834-1_2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002662"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020023"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601773113"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01492-15"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0670-3"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.04.062"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/310207a0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/9.13.2999"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90173-7"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90302-8"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19054-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01394-06"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003749"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90292-3"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/26.12.2891"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7474-3"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02874.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.1.84-94.1997"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.7.3109-3116.1989"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.2741\/2969"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.378"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.2.1132-1141.1995"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.5.2548-2565.2006"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-625"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.008"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01521-10"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06537-11"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007114"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09616"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.020"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191244"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt233"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-615"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpmc.1"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.21.10187-10193.2000"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.11.7309-7314.1995"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00571929"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90433-1"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02517-12"},{"key":"e_1_3_3_53_2","first-page":"4407","article-title":"Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells","volume":"47","author":"Nutter LM","year":"1987","unstructured":"Nutter LM, Grill SP, Li JS, Tan RS, Cheng YC. 1987. Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells. Cancer Res 47:4407\u20134412.","journal-title":"Cancer Res"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.08.013"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.3.1724-1733.2005"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22834-1_6"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.1.9.785"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.2.805"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.8.1690"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02172-06"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001294"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.11.5441-5447.1990"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(88)90546-6"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.116"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.10.7.1001"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki158"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00670-11"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.2741\/1971"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002704"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002376"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00473-06"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01733-08"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.7.3235-3244.2000"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02139-14"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.030"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.6.2192-2201.2003"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02989-13"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw629"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.17.6498"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11334"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00608-15"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02743-06"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.5.2609-2614.2004"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00713-17"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007070"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.27488"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01926-15"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.10.5078-5081.2006"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm170"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02175-10"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.09.012"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00645-10"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92345-1"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0396-342"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1464"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.20.6097"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603095200"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01593-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01593-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:52:20Z","timestamp":1646491940000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01593-18"}},"subtitle":[],"editor":[{"given":"Richard M.","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":98,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1,15]]}},"alternative-id":["10.1128\/JVI.01593-18"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01593-18","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2018-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01593-18"}}