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However, our understanding of how the host cell environment influences AAV transduction is still evolving. In the present study, we investigated the role of\n            <jats:italic>ATP2C1<\/jats:italic>\n            , which encodes a membrane calcium transport pump, SPCA1, essential for maintaining cellular calcium homeostasis on AAV transduction. Our results indicate that cellular calcium is essential for efficient intracellular trafficking and conformational changes in the AAV capsid that support efficient genome transcription. Further, we show that pharmacological modulation of cellular calcium levels can potentially be applied to improve the AAV gene transfer efficiency.\n          <\/jats:p>","DOI":"10.1128\/jvi.01604-20","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T13:58:40Z","timestamp":1597759120000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction"],"prefix":"10.1128","volume":"94","author":[{"given":"Victoria J.","family":"Madigan","sequence":"first","affiliation":[{"name":"Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"},{"name":"Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett 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