{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:24:01Z","timestamp":1789611841885,"version":"build-2803163510"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including antiviral chemotherapy and immunomodulation. This hypothesis was tested in the woodchuck model by a combination of lamivudine pretreatment and subsequent immunizations of woodchucks chronically infected with woodchuck hepatitis virus. The immunizations were performed with DNA vaccines or antigen-antibody immune complexes (IC)\/DNA vaccines. Immunizations with IC\/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection.<\/jats:p>","DOI":"10.1128\/jvi.01613-07","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T01:24:19Z","timestamp":1198718659000},"page":"2598-2603","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Combination of an Antiviral Drug and Immunomodulation against Hepadnaviral Infection in the Woodchuck Model"],"prefix":"10.1128","volume":"82","author":[{"given":"Mengji","family":"Lu","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Virologie, Universita\u0308tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Medical Center of Fudan University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Virologie, Universita\u0308tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Institut fuer Medizinische Virologie, Justus-Liebig-Universitaet Giessen, Giessen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Dahmen","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Allgemeine Viszeral- und Transplantationschirugie, Univesitaetsklinkum Essen, Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Chi","sequence":"additional","affiliation":[{"name":"Klinik fu\u0308r Allgemeine Viszeral- und Transplantationschirugie, Univesitaetsklinkum Essen, Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Dirsch","sequence":"additional","affiliation":[{"name":"Institut fuer Pathologie, Universitaetsklinkum Ko\u0308ln, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thekla","family":"Kemper","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Virologie, Universita\u0308tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Medical Center of Fudan University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Glebe","sequence":"additional","affiliation":[{"name":"Institut fuer Medizinische Virologie, Justus-Liebig-Universitaet Giessen, Giessen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram H.","family":"Gerlich","sequence":"additional","affiliation":[{"name":"Institut fuer Medizinische Virologie, Justus-Liebig-Universitaet Giessen, Giessen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Medical Center of Fudan University, Shanghai, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roggendorf","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Virologie, Universita\u0308tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3731"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23045"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.000333"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/324003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000113804.35096.8E"},{"key":"e_1_3_2_7_2","first-page":"374","volume":"74","year":"2002","unstructured":"Dahmen, U., J. Li, O. Dirsch, M. Fiedler, M. Lu, M. Roggendorf, and C. E. Broelsch. 2002. Liver transplantation in woodchuck: a newly established animal model of hepatitis B reinfection. Transplantation74:374-380.","journal-title":"Transplantation"},{"key":"e_1_3_2_8_2","first-page":"345","volume":"22","year":"2003","unstructured":"Dikici, B., A. G. Kalayci, F. Ozgenc, M. Bosnak, M. Davutoglu, A. Ece, and T. Ozkan. 2003. Therapeutic vaccination in the immunotolerant phase of children with chronic hepatitis B infection. Pediatr. Infect. Dis. J.22:345-349.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2624-2635.2003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3209"},{"key":"e_1_3_2_11_2","first-page":"57","year":"2004","unstructured":"Gerlich, W. H., U. Wend, and D. Glebe. 2004. Quantitative assay of hepatitis B surface antigen in serum or plasma using Laurell electrophoresis, p. 57-63. In J. Lau and R. Hamatake (ed.), Hepatitis B virus protocols. Humana Press, Totowa, NJ.","journal-title":"Hepatitis B virus protocols"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.825"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00063-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80090-6"},{"key":"e_1_3_2_15_2","first-page":"156","volume":"32","year":"2003","unstructured":"Horiike, N., S. M. Fazle Akbar, K. Michitaka, K. Joukou, K. Yamamoto, N. Kojima, and Y. Hiasa. 2003. In vivo immunization by vaccine therapy following virus suppression by lamivudine: a novel approach for treating patients with chronic hepatitis B. J. Clin. Virol.32:156-161.","journal-title":"J. Clin. Virol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17701-0"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00309-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043470"},{"key":"e_1_3_2_20_2","first-page":"328","volume":"3","year":"2003","unstructured":"Le Guerhier, F., A. Thermet, S. Guerret, M. Chevallier, C. Jamard, C. S. Gibbs, and C. Trepo. 2003. Antiviral effect of adefovir in combination with a DNA vaccine in the duck hepatitis B virus infection model. J. Hepatol.3:328-334.","journal-title":"J. Hepatol."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.11.036"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.281-289.1999"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.6368-6376.2005"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00241-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.6.787"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050039"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.8.1269"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20408"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9150"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.1.65-74.1997"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.11.5305-5314.2002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91384-6"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00028-9"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.8.1281"},{"key":"e_1_3_2_35_2","first-page":"210","year":"2005","unstructured":"Roggendorf, M., and M. Lu. 2005. Woodchuck hepatitis virus, p. 210-224. In T. H. Thomas, A. Zuckermann, and S. Lemon (ed.), Viral hepatitis, 3rd ed. Blackwell Publishing Ltd. Oxford, United Kingdom.","journal-title":"Viral hepatitis"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00914.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70188-5"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.11.5036-5042.2001"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.01.038"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.68-76.2003"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.9978-9985.1998"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.09.072"},{"key":"e_1_3_2_43_2","first-page":"1575","volume":"345","year":"1995","unstructured":"Wen, Y. M., X. H. Wu, D. C. Hu, Q. P. Zhang, and S. Q. Guo. 1995. Hepatitis B vaccine and anti-HBs complex as approach for vaccine therapy. Lancet345:1575-1576.","journal-title":"Lancet"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.10.040"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-003-3187-1"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.11.019"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00158-X"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01613-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01613-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:17:32Z","timestamp":1646482652000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01613-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1128\/JVI.01613-07"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01613-07","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"2007-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}