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This virus enters the body in the oropharynx and establishes a chronic infection in this area. The observation that the virus causes tumors in the digestive system implies that the infected cells can move to this organ. We found that EBV infection induces the expression of integrin beta 7 (ITGB7), an integrin that associates with integrin alpha 4 to form the LPAM-1 dimer. LPAM-1 is key for homing of B cells to the gastrointestinal tract, suggesting that induction of this molecule is the mechanism through which EBV-infected cells enter this organ. In favor of this hypothesis, we could also detect EBV-infected cells in the lymph nodes adjacent to the colon and in the appendix.<\/jats:p>","DOI":"10.1128\/jvi.01618-18","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T05:33:59Z","timestamp":1544592839000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Epstein-Barr Virus Induces Expression of the LPAM-1 Integrin in B Cells\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"93","author":[{"given":"Susanne","family":"Delecluse","sequence":"first","affiliation":[{"name":"German Cancer Research Centre (DKFZ), Unit F100, Heidelberg, Germany"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit U1074, Heidelberg, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, 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