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Although a crucial role of CD169\n            <jats:sup>+<\/jats:sup>\n            cells during vesicular stomatitis virus (VSV) infections is increasingly recognized, factors regulating CD169\n            <jats:sup>+<\/jats:sup>\n            cells during viral infections remain unclear. Here, we show that tumor necrosis factor is produced by CD11b\n            <jats:sup>+<\/jats:sup>\n            Ly6C\n            <jats:sup>+<\/jats:sup>\n            Ly6G\n            <jats:sup>+<\/jats:sup>\n            cells following infection with VSV. The absence of TNF or TNF receptor 1 (TNFR1) resulted in reduced numbers of CD169\n            <jats:sup>+<\/jats:sup>\n            cells and in reduced type I interferon (IFN-I) production during VSV infection, with a severe disease outcome. Specifically, TNF triggered RelA translocation into the nuclei of CD169\n            <jats:sup>+<\/jats:sup>\n            cells; this translocation was inhibited when the paracaspase MALT-1 was absent. Consequently, MALT1 deficiency resulted in reduced VSV replication, defective innate immune activation, and development of severe disease. These findings indicate that TNF mediates the maintenance of CD169\n            <jats:sup>+<\/jats:sup>\n            cells and innate and adaptive immune activation during VSV infection.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>IMPORTANCE<\/jats:bold>\n            Over the last decade, strategically placed CD169\n            <jats:sup>+<\/jats:sup>\n            metallophilic macrophages in the marginal zone of the murine spleen and lymph nodes (LN) have been shown to play a very important role in host defense against viral pathogens. CD169\n            <jats:sup>+<\/jats:sup>\n            macrophages have been shown to activate innate and adaptive immunity via \u201cenforced virus replication,\u201d a controlled amplification of virus particles. However, the factors regulating the CD169\n            <jats:sup>+<\/jats:sup>\n            macrophages remain to be studied. In this paper, we show that after vesicular stomatitis virus infection, phagocytes produce tumor necrosis factor (TNF), which signals via TNFR1, and promote enforced virus replication in CD169\n            <jats:sup>+<\/jats:sup>\n            macrophages. Consequently, lack of TNF or TNFR1 resulted in defective immune activation and VSV clearance.\n          <\/jats:p>","DOI":"10.1128\/jvi.01637-17","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T16:15:26Z","timestamp":1510762526000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Tumor Necrosis Factor-Mediated Survival of CD169\n            <sup>+<\/sup>\n            Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection"],"prefix":"10.1128","volume":"92","author":[{"given":"Prashant V.","family":"Shinde","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"},{"name":"Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng C.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"},{"name":"Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathish Kumar","family":"Maney","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, D\u00fcsseldorf, Germany"},{"name":"Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kloetgen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology 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