{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:35:46Z","timestamp":1773902146481,"version":"3.50.1"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI109633"],"award-info":[{"award-number":["U19AI109633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE02633"],"award-info":[{"award-number":["R01DE02633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"HHS | NIH | National Center for Research Resources","doi-asserted-by":"publisher","award":["P30 RR00165"],"award-info":[{"award-number":["P30 RR00165"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008374","name":"Emory University | Center for AIDS Research, Emory University","doi-asserted-by":"publisher","award":["P30 AI050409"],"award-info":[{"award-number":["P30 AI050409"]}],"id":[{"id":"10.13039\/100008374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n            MVA is an attractive viral vector for vaccine development due to its safety and immunogenicity in multiple species and humans even under conditions of immunodeficiency. Here, to further improve the immunogenicity of MVA, we developed a novel vector, MVA-\n            <jats:italic>B13R<\/jats:italic>\n            , by replacing the fragmented anti-apoptotic genes\n            <jats:italic>181R<\/jats:italic>\n            \/\n            <jats:italic>182R<\/jats:italic>\n            with a functional version derived from vaccinia virus,\n            <jats:italic>B13R<\/jats:italic>\n            . Our results show that MVA-\n            <jats:italic>B13R<\/jats:italic>\n            significantly delays apoptosis in antigen-presenting cells and muscle cells\n            <jats:italic>in vitro<\/jats:italic>\n            and augments vaccine-induced humoral immunity in mice, leading to the development of a novel vector for vaccine development against infectious diseases and cancer.\n          <\/jats:p>","DOI":"10.1128\/jvi.01648-18","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T11:32:28Z","timestamp":1544182348000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Novel Modified Vaccinia Virus Ankara Vector Expressing Anti-apoptotic Gene\n            <i>B13R<\/i>\n            Delays Apoptosis and Enhances Humoral Responses"],"prefix":"10.1128","volume":"93","author":[{"given":"Lynette S.","family":"Chea","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sailaja","family":"Gangadhara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-8564","authenticated-orcid":false,"given":"Bernard","family":"Moss","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama R.","family":"Amara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aivir.2016.07.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(83)90163-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10847"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy212"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.08.034"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013983"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.12.026"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-729756"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19041-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00363-18"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1087"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1122-T"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70963-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3361"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2448"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.084"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005445"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00246-12"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024244"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012395"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048524"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032220"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02723-13"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1972.33"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400404"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4161\/onci.26403"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1209"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/89289"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.9.6479-6485.1996"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6822(95)80028-X"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-3-677"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.12.7797"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.18.10377"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9123"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.10.007"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401541"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092140"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-473413"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111457"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100348"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021800"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833d1e87"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/v7041726"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652311795684731"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14191"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3206"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606050113"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401853"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14031-14043.2005"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.078113"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003989"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2091"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092695"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4343"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00126-1"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00208-5"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10696"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40115"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01648-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01648-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T14:52:52Z","timestamp":1646491972000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01648-18"}},"subtitle":[],"editor":[{"given":"Frank","family":"Kirchhoff","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1128\/JVI.01648-18"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01648-18","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"2018-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01648-18"}}