{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:14Z","timestamp":1792787234296,"version":"4.5.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National Research and Development of China","award":["2017YFD0502200"],"award-info":[{"award-number":["2017YFD0502200"]}]},{"name":"the National Natural Science Fund","award":["31772718"],"award-info":[{"award-number":["31772718"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    PEDV is a highly contagious enteric coronavirus that causes significant economic losses, and the lack of a good\n                    <jats:italic>in vitro<\/jats:italic>\n                    model system is a major roadblock to an in-depth understanding of PEDV pathogenesis. Here, we generated a porcine intestinal enteroid model for PEDV infection. Utilizing porcine intestinal enteroids, we demonstrated that PEDV infects multiple lineages of the intestinal epithelium and preferably infects ileal enteroids over colonoids and that enteroids prefer to respond to IFN lambda 1 over IFN-\u03b1. These events recapitulate the events that occur\n                    <jats:italic>in vivo<\/jats:italic>\n                    . This study constitutes the first use of a primary intestinal enteroid model to investigate the susceptibility of porcine enteroids to PEDV and to determine the antiviral response following infection. Our study provides important insights into the events associated with PEDV infection of the porcine intestine and provides a valuable\n                    <jats:italic>in vitro<\/jats:italic>\n                    model for studying not only PEDV but also other swine enteric viruses.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01682-18","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T05:07:38Z","timestamp":1544677658000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":87,"title":["Porcine Intestinal Enteroids: a New Model for Studying Enteric Coronavirus Porcine Epidemic Diarrhea Virus Infection and the Host Innate Response"],"prefix":"10.1128","volume":"93","author":[{"given":"Liang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 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