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We evaluated the efficacy of KPT-335 as an anti-RSV drug and show that KPT-335 inhibits XPO1-mediated nuclear export, leading to nuclear accumulation of RSV M protein and reduction in RSV levels. KPT-335 treatment also resulted in inhibition of proinflammatory pathways, which has important implications for its effectiveness\n            <jats:italic>in vivo<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/jvi.01684-18","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T11:32:40Z","timestamp":1544182360000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication\n            <i>In Vitro<\/i>"],"prefix":"10.1128","volume":"93","author":[{"given":"Patricia A.","family":"Jorquera","sequence":"first","affiliation":[{"name":"Animal Health Research Center, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Mathew","sequence":"additional","affiliation":[{"name":"Respiratory Virology Group, Centre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pickens","sequence":"additional","affiliation":[{"name":"Animal Health Research Center, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Williams","sequence":"additional","affiliation":[{"name":"Animal Health Research Center, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina M.","family":"Luczo","sequence":"additional","affiliation":[{"name":"Animal Health Research Center, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Tamir","sequence":"additional","affiliation":[{"name":"Karyopharm Therapeutics, Inc., Newton, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Ghildyal","sequence":"additional","affiliation":[{"name":"Respiratory Virology Group, Centre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-9956","authenticated-orcid":false,"given":"Ralph A.","family":"Tripp","sequence":"additional","affiliation":[{"name":"Animal Health Research Center, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1758"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043951"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199910)59:2<221::AID-JMV16>3.0.CO;2-H"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000959"},{"key":"e_1_3_2_6_2","first-page":"341","volume-title":"The biology of paramyxoviruses","author":"Collins PL","year":"2011","unstructured":"Collins PL. 2011. 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