{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:45:58Z","timestamp":1790660758126,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-LABX-77"],"award-info":[{"award-number":["ANR-LABX-77"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:p>\n                    A small minority of HIV-infected patients, called HIV controllers (HIC), maintains spontaneous control of HIV replication. It is therefore important to identify mechanisms that contribute to the control of HIV replication that may have implications for vaccine design. We observed a low inflammation, a downmodulation of natural killer inhibitory cell signaling, and an upregulation of T-cell activation gene expression in the blood of HIC compared to patients under combined antiretroviral treatment. This profile persists following\n                    <jats:italic>in vitro<\/jats:italic>\n                    stimulation of peripheral blood mononuclear cells with HIV antigens, and was consistent with functional analyses showing a Th1 and cytotoxic T cell response and a lower production of inflammatory cytokines. These results reveal significant features of HIC that maintain strong HIV-specific immune responses with low levels of inflammation. These findings define the immune status of HIC that is probably associated with the control of viral load.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01690-18","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T05:49:07Z","timestamp":1551246547000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood"],"prefix":"10.1128","volume":"93","author":[{"given":"Hakim","family":"Hocini","sequence":"first","affiliation":[{"name":"INSERM U955, IMRB \u00c9quipe 16, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"Vaccine Research Institute-VRI, H\u00f4pital Henri Mondor, Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine, Cr\u00e9teil, 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