{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:19:22Z","timestamp":1774441162386,"version":"3.50.1"},"reference-count":76,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100007197","name":"HHS | U.S. Public Health Service","doi-asserted-by":"publisher","award":["CA180758"],"award-info":[{"award-number":["CA180758"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,3,31]]},"abstract":"<jats:p>\n            Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) manipulates several cellular pathways for its survival advantage during its latency in the infected human host. Here, we demonstrate that KSHV infection upregulates the expression of genes related to neuronal and neuroendocrine (NE) functions that are characteristic of NE tumors, both\n            <jats:italic>in vitro<\/jats:italic>\n            and in KS patient tissues and the heterogeneity of neuroendocrine receptors having opposing roles in KSHV-infected cell proliferation. Induction of NE genes by KSHV could also provide a potential survival advantage, as the expression of proteins at immunologically privileged sites such as neurons on endothelial cells may be an avenue to escape host immune surveillance functions. The NE gene products identified here could serve as markers for KSHV-infected cells and could potentially serve as therapeutic targets to combat KSHV-associated KS.\n          <\/jats:p>","DOI":"10.1128\/jvi.01692-19","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T09:34:06Z","timestamp":1579685646000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Kaposi\u2019s Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells"],"prefix":"10.1128","volume":"94","author":[{"given":"Mohanan","family":"Valiya Veettil","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunava","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anandita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipanjan","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-8501","authenticated-orcid":false,"given":"Binod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayan","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology A-STAR, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thoppil Raveendran","family":"Anju","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Sharma-Walia","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bala","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40567"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2888"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02723-09"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.7.3601-3620.2004"},{"key":"e_1_3_3_9_2","first-page":"87","volume-title":"Advances in virus research","author":"Cai Q","year":"2010","unstructured":"Cai Q, Verma SC, Lu J, Robertson ES. 2010. 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