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The Can strain, derived from the pathogenic XJ strain of JUNV, has been demonstrated to be both safe and protective against AHF. While the vaccine strain is approved for use in regions of endemicity within Argentina, the mechanisms of Can attenuation have not been elucidated. A better understanding of the viral genetic determinants of attenuation will improve our understanding of the mechanisms contributing to disease pathogenesis and provide critical information for the rational design of live attenuated vaccine candidates for other viral hemorrhagic fevers.<\/jats:p>","DOI":"10.1128\/jvi.01693-19","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T10:04:52Z","timestamp":1580465092000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome"],"prefix":"10.1128","volume":"94","author":[{"given":"John T.","family":"Manning","sequence":"first","affiliation":[{"name":"University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadya E.","family":"Yun","sequence":"additional","affiliation":[{"name":"Boston University, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey V.","family":"Seregin","sequence":"additional","affiliation":[{"name":"Solid Biosciences, Cambridge, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Koma","sequence":"additional","affiliation":[{"name":"Tokushima University, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A.","family":"Sattler","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiomah","family":"Ezeomah","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Scripps Research Institute, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Paessler","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch, Galveston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1283","volume-title":"Fields virology","author":"Buchmeier MJ","year":"2013","unstructured":"Buchmeier MJ, De la Torre JC, Peters CJ. 2013. 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