{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:30:14Z","timestamp":1782937814838,"version":"3.54.5"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R08AI074907"],"award-info":[{"award-number":["R08AI074907"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01AI043681"],"award-info":[{"award-number":["P01AI043681"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI063565"],"award-info":[{"award-number":["U01AI063565"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI136556"],"award-info":[{"award-number":["R21AI136556"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["DP2HD075699"],"award-info":[{"award-number":["DP2HD075699"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["F30HD089577"],"award-info":[{"award-number":["F30HD089577"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n                    Though not a household name like Zika virus, human cytomegalovirus (HCMV) causes permanent neurologic disability in one newborn child every hour in the United States, which is more than that for Down syndrome, fetal alcohol syndrome, and neural tube defects combined. There are currently no established effective measures to prevent viral transmission to the infant following HCMV infection of a pregnant mother. However, the glycoprotein B (gB)\/MF59 vaccine, which aims to prevent pregnant women from acquiring HCMV, is the most successful HCMV vaccine tested clinically to date. Here, we used viral DNA isolated from patients enrolled in a gB vaccine trial who acquired HCMV and identified several impacts that this vaccine had on the size, distribution, and composition of the\n                    <jats:italic>in vivo<\/jats:italic>\n                    viral population. These results have increased our understanding of why the gB\/MF59 vaccine was partially efficacious, and such investigations will inform future rational design of a vaccine to prevent congenital HCMV.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01695-18","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T11:14:37Z","timestamp":1543922077000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Intrahost Dynamics of Human Cytomegalovirus Variants Acquired by Seronegative Glycoprotein B Vaccinees"],"prefix":"10.1128","volume":"93","author":[{"given":"Cody S.","family":"Nelson","sequence":"first","affiliation":[{"name":"Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Vera Cruz","sequence":"additional","affiliation":[{"name":"Department of Computational Biology and Bioinformatics, Duke University, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Su","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Xie","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Vandergrift","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Pass","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Diener-West","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Koelle","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-167X","authenticated-orcid":false,"given":"Ravit","family":"Arav-Boger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie R.","family":"Permar","sequence":"additional","affiliation":[{"name":"Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2013.45.3.260"},{"key":"e_1_3_3_5_2","volume-title":"Vaccines for the 21st century: a tool for decisionmaking","author":"Stratton KR","year":"2000","unstructured":"Stratton KR, Durch JS, Lawrence RS. (ed). 2000. Vaccines for the 21st century: a tool for decisionmaking. National Academies Press, Washington, DC."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804749"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.11.056"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60136-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800177115"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800224115"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-018-0074-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015949"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79888-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18606-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb27976.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21241"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/421496"},{"key":"e_1_3_3_18_2","first-page":"1183","article-title":"Cytomegalovirus glycoprotein B genotyping in ocular fluids and blood of AIDS patients with cytomegalovirus retinitis","volume":"39","author":"Peek R","year":"1998","unstructured":"Peek R, Verbraak F, Bruinenberg M, Van der Lelij A, Van den Horn G, Kijlstra A. 1998. Cytomegalovirus glycoprotein B genotyping in ocular fluids and blood of AIDS patients with cytomegalovirus retinitis. Invest Ophthalmol Vis Sci 39:1183\u20131187.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21459"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20210"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001344"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003735"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501880112"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01079-07"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94002"},{"key":"e_1_3_3_26_2","doi-asserted-by":"crossref","unstructured":"Nelson CS Vera Cruz D Su M Xie G Vandergrift N Pass RF Forman M Diener-West M Koelle K Arav-Boger R Permar SR. 1995. Genetic signatures of human cytomegalovirus variants acquired by seronegative glycoprotein B vaccinees. bioRxiv doi:10.1101\/432922.","DOI":"10.1101\/432922"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1201"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir632"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix188"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02268-06"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.2.387"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/47.6.713"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/61.3.763"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.2.878-886.1999"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.3.1303-1311.1992"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-9-2375"},{"key":"e_1_3_3_37_2","first-page":"26","article-title":"The product of human cytomegalovirus UL73 is a new polymorphic structural glycoprotein (gpUL73)","volume":"4","author":"Dal Monte P","year":"2001","unstructured":"Dal Monte P, Pignatelli S, Mach M, Landini MP. 2001. The product of human cytomegalovirus UL73 is a new polymorphic structural glycoprotein (gpUL73). J Hum Virol 4:26\u201334.","journal-title":"J Hum Virol"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.056"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02442-10"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703661"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002172"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt593"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90771-G"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2014.11.026"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/132.2.583"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/155.4.2011"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/123.3.603"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.23.11686-11699.2001"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a040023"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0203s00"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbn017"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-71"},{"key":"e_1_3_3_53_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57:289\u2013300.","journal-title":"J R Stat Soc Series B Stat Methodol"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01695-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01695-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T20:30:25Z","timestamp":1720816225000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01695-18"}},"subtitle":[],"editor":[{"given":"Jae U.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1128\/JVI.01695-18"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01695-18","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/432922","asserted-by":"object"}]},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"2018-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01695-18"}}