{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:24:44Z","timestamp":1787019884634,"version":"build-2736575974"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81525018"],"award-info":[{"award-number":["81525018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFA0707401"],"award-info":[{"award-number":["2020YFA0707401"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Hepatitis B virus (HBV) infection can be effectively suppressed but rarely cured by available drugs. Chronic HBV infection is based on persistence of covalently closed circular DNA (cccDNA) and continuous infection and reinfection with HBV in the liver.<\/jats:p>","DOI":"10.1128\/jvi.01717-22","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T09:00:37Z","timestamp":1670403637000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Nonproductive Hepatitis B Virus Covalently Closed Circular DNA Generates HBx-Related Transcripts from the HBx\/Enhancer I Region and Acquires Reactivation by Superinfection in Single Cells"],"prefix":"10.1128","volume":"97","author":[{"given":"Bo","family":"Peng","sequence":"first","affiliation":[{"name":"Graduate program in School of Life Sciences, Peking University, Beijing, China"},{"name":"National Institute of Biological Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Jing","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Graduate program in School of Life Sciences, Beijing Normal University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyan","family":"Sun","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilan","family":"Guo","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Graduate program in School of Life Sciences, Beijing Normal University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Tan","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Diao","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Graduate program in School of Life Sciences, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyan","family":"Yao","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Graduate program, Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ping","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelei","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Ren","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-7404","authenticated-orcid":true,"given":"Wenhui","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences, Beijing, China"},{"name":"Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30119-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01703079"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01391-17"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2033898100"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb02113.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(85)80125-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90157-x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309809"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.02.031"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22881"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.019224-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000307"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.028"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.015"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2018.01.007"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17170"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169648"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322571"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140584"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83339"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz607"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01625-16"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky182"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.3.566"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.69.6.3647-3657.1995"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.3.2026-2030.1994"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25928"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32942"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32303"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62586"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.133926.111"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02007-17"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab469"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1507"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.003"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00248-19"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.3.329"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.09.017"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00049"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6700-1_1"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005893"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26738"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1237"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01717-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01717-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T09:17:52Z","timestamp":1675156672000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01717-22"}},"subtitle":[],"editor":[{"given":"J.-H. James","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,31]]}},"alternative-id":["10.1128\/jvi.01717-22"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01717-22","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]},"assertion":[{"value":"2022-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01717-22"}}