{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:31:19Z","timestamp":1790937079866,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["320030_173071"],"award-info":[{"award-number":["320030_173071"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n            and human immunodeficiency virus (HIV) infections are coendemic in several regions of the world, and\n            <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n            \/HIV-coinfected individuals are more susceptible to progression to tuberculosis disease. We therefore hypothesized that HIV infection would potentially impair\n            <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n            -specific protective immunity in individuals suffering from latent tuberculosis infection (LTBI) or active pulmonary tuberculosis (PTB). In this study, we demonstrated that\n            <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n            \/HIV-coinfected individuals have fewer circulating\n            <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n            -specific CD4 T cells and that those that remained were functionally impaired in both LTBI and PTB settings. In addition, we showed that HIV infection significantly interferes with\n            <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n            -induced systemic proinflammatory cytokine\/chemokine responses. Taken together, these data suggest that HIV infection impairs functionally favorable\n            <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n            -specific immunity.\n          <\/jats:p>","DOI":"10.1128\/jvi.01728-18","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T10:34:58Z","timestamp":1544610898000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses"],"prefix":"10.1128","volume":"93","author":[{"given":"Patrizia","family":"Amelio","sequence":"first","affiliation":[{"name":"Service of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, Lausanne, 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