{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:25:41Z","timestamp":1790720741046,"version":"4.1.0"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To model human immunodeficiency virus (HIV) perinatal transmission, we studied infection of simian-human immunodeficiency virus (SHIV) SF162P3 in 10 pregnant\n            <jats:italic>Macaca nemestrina<\/jats:italic>\n            females and their offspring. Four of nine infants born to and suckled by these dams had evidence of infection, a transmission rate of 44.4% (95% confidence interval, 13.7% to 78.8%). We quantified transplacentally acquired and de novo Env-specific immunoglobulin G (IgG), IgM, and neutralizing antibodies in newborns. Transmission of escape variants was confirmed. In utero infection (\n            <jats:italic>n<\/jats:italic>\n            = 1) resulted in high viremia, depletion of peripheral CD4\n            <jats:sup>+<\/jats:sup>\n            T cells, and rapid evolution of\n            <jats:italic>env<\/jats:italic>\n            in blood and tissues. Peripartum or postpartum SHIV infection (\n            <jats:italic>n<\/jats:italic>\n            = 3) resulted in postacute viral control that was undetectable by very sensitive multiplex PCR, despite increasing antibodies. Seropositive infants with highly controlled viremia had homogeneous peripheral blood\n            <jats:italic>env<\/jats:italic>\n            sequences, and their tissues had &lt;3 copies per million cells. A high incidence of seropositive virus-low or -negative SHIV infection in infant macaques has implications for HIV type 1 perinatal transmission and detection.\n          <\/jats:p>","DOI":"10.1128\/jvi.01759-06","type":"journal-article","created":{"date-parts":[[2006,12,27]],"date-time":"2006-12-27T23:52:56Z","timestamp":1167263576000},"page":"822-834","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Evidence for Persistent, Occult Infection in Neonatal Macaques following Perinatal Transmission of Simian-Human Immunodeficiency Virus SF162P3"],"prefix":"10.1128","volume":"81","author":[{"given":"Pushpa","family":"Jayaraman","sequence":"first","affiliation":[{"name":"Departments of Pathobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuofu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory Medicine"},{"name":"Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Misher","sequence":"additional","affiliation":[{"name":"Seattle Biomedical Research Institute, Seattle, Washington 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Mohan","sequence":"additional","affiliation":[{"name":"Seattle Biomedical Research Institute, Seattle, Washington 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LaRene","family":"Kuller","sequence":"additional","affiliation":[{"name":"National Primate Research Center, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Polacino","sequence":"additional","affiliation":[{"name":"National Primate Research Center, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbra A.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Biostatistics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Bielefeldt-Ohmann","sequence":"additional","affiliation":[{"name":"National Primate Research Center, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Anderson","sequence":"additional","affiliation":[{"name":"National Primate Research Center, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu-Lok","family":"Hu","sequence":"additional","affiliation":[{"name":"Microbiology"},{"name":"Pharmaceutics"},{"name":"National Primate Research Center, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Haigwood","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology"},{"name":"Microbiology"},{"name":"Seattle Biomedical Research Institute, Seattle, Washington 98109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0684.2003.00024.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-1-17"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1994.10.351"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/503778"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/415335a"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.2.999-1014.2006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(01)00263-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg500"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.5.1279"},{"key":"e_1_3_2_11_2","first-page":"133","volume":"39","year":"2005","unstructured":"Fiebig, E. 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