{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:20:54Z","timestamp":1790623254426,"version":"4.1.0"},"reference-count":74,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Government of New Caledonia"},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche Medicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:p>\n                    The reemergence of chikungunya virus (CHIKV), an alphavirus that is transmitted to humans by\n                    <jats:italic>Aedes<\/jats:italic>\n                    mosquitoes, is a serious global health threat. In the absence of effective antiviral drugs, CHIKV infection has a significant impact on human health, with chronic arthritis being one of the most serious complications. The molecular understanding of host-virus interactions is a prerequisite to the development of targeted therapeutics capable to interrupt viral replication and transmission. Here, we identify the host cell DHX9 DExH-Box helicase as an essential cofactor for early CHIKV genome translation. We demonstrate that CHIKV nsP3 protein acts as a key factor for DHX9 recruitment to replication complexes. Finally, we establish that DHX9 behaves as a switch that regulates the progression of the viral cycle from translation to genome replication. This study might therefore have a significant impact on the development of antiviral strategies.\n                  <\/jats:p>","DOI":"10.1128\/jvi.01764-18","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T05:14:26Z","timestamp":1542863666000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0289-324X","authenticated-orcid":false,"given":"Roy","family":"Matkovic","sequence":"first","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bernard","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fontanel","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3678-1043","authenticated-orcid":false,"given":"Patrick","family":"Eldin","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Chazal","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deka","family":"Hassan Hersi","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-0071","authenticated-orcid":false,"given":"Andres","family":"Merits","sequence":"additional","affiliation":[{"name":"Institute of Technology, University of Tartu, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-9703","authenticated-orcid":false,"suffix":"Jr.","given":"Jean-Marie","family":"P\u00e9lopon\u00e8se","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-3501","authenticated-orcid":false,"given":"Laurence","family":"Briant","sequence":"additional","affiliation":[{"name":"IRIM, CNRS UMR9004\u2013University Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.06.009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000249"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00477-10"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.11.3164"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06587.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06390-11"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603980200"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01105-13"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01983-09"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200202035"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.11.161"},{"key":"e_1_3_2_13_2","first-page":"555","article-title":"Relevance of nuclear localization and functions of RNA helicase A","volume":"15","author":"Fujita H","year":"2005","unstructured":"Fujita H, Ohshima T, Oishi T, Aratani S, Fujii R, Fukamizu A, Nakajima T. 2005. 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