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The focus of this work is to address the question of the mechanisms underlying RVFV-induced cytopathic effects that participate in RVFV pathogenicity. We demonstrate here that RVFV targets cell adhesion and the actin cytoskeleton at the transcriptional and cellular level, affecting cell mobility and inducing cell shape collapse, along with distortion of cell-cell adhesion. All these effects may participate in RVFV-induced pathogenicity, facilitate virulent RVFV dissemination, and thus constitute interesting potential targets for future development of antiviral therapeutic strategies that, in the case of RVFV, as with several other emerging arboviruses, are presently lacking.<\/jats:p>","DOI":"10.1128\/jvi.01768-20","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T14:20:39Z","timestamp":1603376439000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion"],"prefix":"10.1128","volume":"95","author":[{"given":"Aline","family":"Bamia","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes, INSERM UMRS-1007 CICB-Paris, 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