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Yet upon complementation through coinfection with fully infectious standard virus (STV), interference with the viral life cycle can be observed, leading to suppressed STV replication and the release of mainly noninfectious DIPs. Interestingly, recent research indicates that DIPs may serve as an antiviral agent. Here we report the discovery of a yet-unknown type of influenza A virus-derived DIP (termed \u201cOP7\u201d virus) that contains numerous point mutations instead of large deletions in its genome. Furthermore, the underlying principles that render OP7 virions interfering and apparently defective seem to differ from those of conventional DIPs. In conclusion, we believe that OP7 virus might be a promising candidate for antiviral therapy. Moreover, it exerts strong effects, both on virus replication and on the host cell response, and may have been overlooked in other IAV preparations.<\/jats:p>","DOI":"10.1128\/jvi.01786-18","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T12:56:05Z","timestamp":1542804965000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-9718","authenticated-orcid":false,"given":"Sascha Young","family":"Kupke","sequence":"first","affiliation":[{"name":"Max Planck Institute for Dynamics of Complex Technical Systems, Department of Bioprocess Engineering, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Riedel","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Biophysical Chemistry, Facility for Transmission Electron Microscopy, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Frensing","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Dynamics of Complex Technical Systems, Department of Bioprocess Engineering, Magdeburg, Germany"},{"name":"Otto von Guericke University Magdeburg, Chair of Bioprocess Engineering, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Zmora","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Dynamics of Complex Technical Systems, Department of Bioprocess Engineering, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Reichl","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Dynamics of Complex Technical Systems, Department of Bioprocess Engineering, Magdeburg, Germany"},{"name":"Otto von Guericke University Magdeburg, Chair of Bioprocess Engineering, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/226325a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.641"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03193-13"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/v7072796"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2014.06.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02741-12"},{"key":"e_1_3_2_8_2","first-page":"151","article-title":"Origin and replication of defective interfering particles","volume":"93","author":"Perrault J","year":"1981","unstructured":"Perrault J. 1981. 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