{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:32:00Z","timestamp":1790742720731,"version":"4.1.0"},"reference-count":97,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Fondation Ernst and Margarete Wagemann"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Cluster of Excellence 2155 RESIST"],"award-info":[{"award-number":["Cluster of Excellence 2155 RESIST"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","award":["Project 07.802"],"award-info":[{"award-number":["Project 07.802"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,2,14]]},"abstract":"<jats:p>Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) is the cause of three human malignancies: Kaposi\u2019s sarcoma, primary effusion lymphoma, and the plasma cell variant of multicentric Castleman disease. Previous research has shown that several cellular tyrosine kinases play crucial roles during several steps in the virus replication cycle.<\/jats:p>","DOI":"10.1128\/jvi.01791-19","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T13:43:59Z","timestamp":1575985439000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Targeting Kaposi's Sarcoma-Associated Herpesvirus ORF21 Tyrosine Kinase and Viral Lytic Reactivation by Tyrosine Kinase Inhibitors Approved for Clinical Use"],"prefix":"10.1128","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-5987","authenticated-orcid":false,"given":"Guillaume","family":"Beauclair","sequence":"first","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"},{"name":"German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Naimo","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"},{"name":"German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Dubich","sequence":"additional","affiliation":[{"name":"Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"R\u00fcckert","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"},{"name":"German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"},{"name":"German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"},{"name":"German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wirth","sequence":"additional","affiliation":[{"name":"Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany"},{"name":"Institute for Experimental Hematology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8792-5345","authenticated-orcid":false,"given":"Thomas F.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Institute of Virology, Hannover Medical School, Hannover, Germany"},{"name":"German Centre for Infection Research, Hannover-Braunschweig Site, Hannover, Germany"},{"name":"Excellence Cluster 2155 RESIST, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC cancer base no. 11","author":"Ferlay J","year":"2013","unstructured":"Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2013. GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC cancer base no. 11. International Agency for Research on Cancer, Lyon, France."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-3-11"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.057"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00689-06"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003750"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00283-14"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002054"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.7.3601-3620.2004"},{"key":"e_1_3_2_10_2","first-page":"1517","article-title":"Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman\u2019s disease","volume":"151","author":"Parravicini C","year":"1997","unstructured":"Parravicini C, Corbellino M, Paulli M, Magrini U, Lazzarino M, Moore PS, Chang Y. 1997. Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman\u2019s disease. Am J Pathol 151:1517\u20131522.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.8.2871"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64940-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001065107"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/654798"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5293.1739"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14383-14391.2005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.12.4034.412k38_4034_4043"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407382200"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.8386"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.7.3421-3439.2002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/385347a0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.1.839-842.1997"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0397-287"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200007)61:3<332::aid-jmv8>3.0.co;2-3"},{"key":"e_1_3_2_25_2","first-page":"501","article-title":"Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes","volume":"10","author":"Foussat A","year":"1999","unstructured":"Foussat A, Wijdenes J, Bouchet L, Gaidano G, Neipel F, Balabanian K, Galanaud P, Couderc J, Emilie D. 1999. Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes. Eur Cytokine Netw 10:501\u2013508.","journal-title":"Eur Cytokine Netw"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1151.004k37_1151_1157"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.124"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.3.2232-2242.1999"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00648-06"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82807-0"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.8.6953-6963.1999"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.17.9346-9358.2003"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.11.8218-8223.1996"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.12.6761-6768.2003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00553-06"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.025494-0"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01192-15"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00962"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/v6114731"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.2.684-692.2000"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03957-14"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1721"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-317610"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490358"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.23.14647-14659.2005"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.010603-0"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4736"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.4.2410-2417.2003"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404521102"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0274"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00506-13"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-018-01733-1"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200009290-00006"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1159\/000051697"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2069"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1086\/593567"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00073"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.079"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.6365"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.05.011"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.16.8383-8399.2002"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1990"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903383427"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.5891-5898.2001"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2781"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-11-240"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003360"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2805"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003510"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119592109"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-594432"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.12.005"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.7906"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0510-8"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005060635"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.09.025"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904083401402"},{"key":"e_1_3_2_78_2","doi-asserted-by":"crossref","unstructured":"Jochmann R Lorenz P Chudasama P Zietz C St\u00fcrzl M Konrad A. 2012. KSHV paracrine effects on tumorigenesis Herpesviridae\u2014a look into this unique family of viruses. InTech Open https:\/\/www.intechopen.com\/books\/herpesviridae-a-look-into-this-unique-family-of-viruses\/kshv-paracrine-effects-on-tumorigenesis.","DOI":"10.5772\/27908"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro958"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/2042-4280-2-3"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4441"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.07.008"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2015.08.016"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006639"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-125-32029"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.03.049"},{"key":"e_1_3_2_87_2","first-page":"276","article-title":"Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt\u2019s lymphoma","volume":"22","author":"Menezes J","year":"1975","unstructured":"Menezes J, Leibold W, Klein G, Clements G. 1975. Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt\u2019s lymphoma. Biomedicine 22:276\u2013284.","journal-title":"Biomedicine"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2009.0184"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00226-11"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2417-5"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27849"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900201)65:3<492::AID-CNCR2820650320>3.0.CO;2-C"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2015.02.022"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-652-8_30"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01019-12"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003737"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-10-r100"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.10.021"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01791-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01791-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:05:04Z","timestamp":1646492704000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01791-19"}},"subtitle":[],"editor":[{"given":"Richard M.","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,14]]},"references-count":97,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,2,14]]}},"alternative-id":["10.1128\/JVI.01791-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01791-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,14]]},"assertion":[{"value":"2019-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01791-19"}}