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The blood\u2013brain barrier (BBB) is comprised of brain endothelial cells (BECs) that stringently regulate the passage of molecules, toxins, and pathogens from the circulation into the CNS. Through their unique properties, such as complex tight junctions, reduced rates of endocytosis, expression of efflux transporters, and restricted expression of leukocyte adhesion molecules, the BBB is often able to limit pathogen entry into the brain; however, certain neurotropic pathogens, such as coxsackievirus B3 (CVB3) are able to infect the CNS. We have previously demonstrated that CVB3 can infect and disrupt induced pluripotent stem cell-derived brain-like endothelial cells (iBECs), but the host response to this infection remains unknown. Here, we investigate global host transcriptional changes during CVB3 infection of iBECs using RNA sequencing. We validated our data set by exploring pathways altered by CVB3 using quantitative real-time PCR (qPCR) and enzyme-linked immunosorbent assay of upregulated cytokines and interferon signaling molecules.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>IMPORTANCE<\/jats:title>\n            <jats:p>Coxsackievirus B3 (CVB3) is a leading cause of viral aseptic meningitis that can produce severe disease in susceptible individuals. To gain access to the central nervous system, CVB3 must cross central nervous system barriers, such as the blood\u2013brain barrier. Previously, we have shown that CVB3 infects a human stem cell-derived brain-like endothelial cell model. Here, we report the global transcriptome of stem cell-derived brain-like endothelial cells to CVB3 infection and provide proof-of-concept validation of the dataset using molecular biology techniques. These data could inform novel mechanisms of CVB3-mediated blood\u2013brain barrier dysfunction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/jvi.01824-24","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T14:00:43Z","timestamp":1734098443000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Transcriptomic analysis of coxsackievirus B3 infection in induced pluripotent stem cell-derived brain-like endothelial cells"],"prefix":"10.1128","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6699-3263","authenticated-orcid":false,"given":"Sarah F.","family":"Hathcock","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5047-961X","authenticated-orcid":false,"given":"Julia","family":"Mamana","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8185-4636","authenticated-orcid":false,"given":"Taryn E.","family":"Keyzer","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Vollmuth","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8037-8940","authenticated-orcid":false,"given":"Mohammad-Reza","family":"Shokri","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Mauser","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Correll","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]},{"name":"Center for Convergent Biosciences and Medicine, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0476-8028","authenticated-orcid":false,"given":"Brandon J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]},{"name":"Center for Convergent Biosciences and Medicine, The University of Alabama","place":["Tuscaloosa, USA"]},{"name":"Department of Microbiology, Heersink School of Medicine, The University of Alabama at Birmingham","place":["Birmingham, USA"]},{"name":"Alabama Life Research Institute, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-3223","authenticated-orcid":false,"given":"Jon","family":"Sin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, The University of Alabama","place":["Tuscaloosa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01347-17"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.6.1019"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.888"},{"key":"e_1_3_4_5_2","first-page":"371","article-title":"Neonatal coxsackievirus group B infections: experience of a single department of neonatology","volume":"30","author":"Isacsohn M","year":"1994","unstructured":"Isacsohn M, Eidelman AI, Kaplan M, Goren A, Rudensky B, Handsher R, Barak Y. 1994. 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