{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:18:47Z","timestamp":1788931127033,"version":"build-2803163510"},"reference-count":91,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2025,12,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>The human-specific gammaherpesviruses Epstein-Barr virus and Kaposi\u2019s sarcoma-associated herpesvirus infect &gt;95% of all adults, establish lifelong infections, and are associated with multiple different cancers, including B-cell lymphomas. These viruses naturally infect B cells and drive a unique and robust germinal center response to establish their latent viral reservoir in memory B cells. The unique and robust nature of the virus-driven germinal center response increases the risk for B-cell transformation, which is why many gammaherpesvirus-associated cancers are derived from germinal center or post-germinal center B cells. We have previously reported that both global and T cell-specific host IL-17RA signaling is proviral in the context of gammaherpesvirus infection by promoting the virus-driven germinal center response and establishment of latent viral infection. In this study, we examine the role of B cell-specific IL-17RA signaling in the context of gammaherpesvirus infection, given these viruses\u2019 reliance on B cells to establish and maintain lifelong infection. Similarly, to what we observed in the context of global and T cell-specific IL-17RA signaling, we found that B cell-intrinsic IL-17RA signaling supports the establishment of viral latency and reactivation in the spleen and peritoneal cavity, as well as promotes the virus-driven germinal center response. Our study reveals the proviral role of B cell-intrinsic IL-17RA signaling in supporting the establishment of chronic gammaherpesvirus infection.<\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>Gammaherpesviruses are lifelong pathogens that are prevalent in over 95% of all adults. These viruses are tumorigenic and associated with multiple cancers, including B-cell lymphomas. They are B-cell tropic viruses that manipulate the germinal center response to establish their latent viral reservoir in memory B cells. This manipulation of the germinal center response is thought to be the target of viral transformation, leading to lymphomagenesis as most gammaherpesvirus-associated cancers are germinal center or post-germinal center derived. In this study, we developed a new mouse model to understand the B cell-intrinsic role of IL-17RA signaling in gammaherpesvirus infection. Previous studies have shown that IL-17RA signaling is proviral in the context of gammaherpesvirus infection, and this study found that while B cell-intrinsic IL-17RA signaling is not the sole factor behind the systemic proviral role of IL-17RA signaling, it plays an important role in the virus-driven germinal center response, the expansion of B-1 B cells, and the establishment of chronic gammaherpesvirus infection.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/jvi.01842-25","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:44:24Z","timestamp":1764776664000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["B cell-intrinsic interleukin 17 receptor A signaling supports the establishment of chronic murine gammaherpesvirus 68 infection"],"prefix":"10.1128","volume":"99","author":[{"given":"Sheikh Tahir","family":"Majeed","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04j198w64","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Investigative Medicine and Center for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine","place":["Kalamazoo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Huss","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04j198w64","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Investigative Medicine and Center for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine","place":["Kalamazoo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Bradford","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04j198w64","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Investigative Medicine and Center for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine","place":["Kalamazoo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3421-8185","authenticated-orcid":true,"given":"Christopher N.","family":"Jondle","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04j198w64","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Investigative Medicine and Center for Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine","place":["Kalamazoo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104656"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens5010018"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-072710-081639"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-71-6-1365"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.23.14668-14679.2005"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.8.5894-5904.1997"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020890"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.5.2891-2899.2005"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.4.567"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2385"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.12.4044"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02609-08"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00297-09"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02469"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03147"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18470"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature714"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1201"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200009290-00006"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21096"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh313"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02579.x"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700499200"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2007.35"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.36"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.006"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.149831"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C600256200"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604597200"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3742"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302265"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3908061"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01894"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44050127"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.130"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01234-17"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005367"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00402-22"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.5797-5801.1998"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90070-5"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0240"},{"key":"e_1_3_5_44_2","first-page":"14946","article-title":"Investigation for the roles of TLR2, TLR9 and Th17\/Treg in the pathogenesis of infectious mononucleosis","volume":"10","author":"Gao A","year":"2017","unstructured":"Gao A, Shao Y. 2017. Investigation for the roles of TLR2, TLR9 and Th17\/Treg in the pathogenesis of infectious mononucleosis. Int J Clin Exp Med 10:14946\u201314953.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13090747"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00566-21"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2024.110153"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.1820"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12069"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.17.4.619-624.1983"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00639-22"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-024-00214-z"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502641"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1030560"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901206"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1552"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1VMR0216-096RR"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903133"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009234107"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.02.022"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01103-17"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.007"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.6.1317"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.73"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.009"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-010116"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39734-5"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04433-9"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-024-00455-y"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12137"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.12.001"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02572-09"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02071-18"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.4.3273-3283.1999"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00186-08"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00111-09"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030011"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01202"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0367-4"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-019-0678-9"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701440"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121225"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.08.007"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.991188"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102484"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.14.8144"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000854"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.12b.2598"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.08.019"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.05.027"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02774-15"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01760-18"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01842-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.01842-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:04:50Z","timestamp":1766498690000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.01842-25"}},"subtitle":[],"editor":[{"given":"Lori","family":"Frappier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":91,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,23]]}},"alternative-id":["10.1128\/jvi.01842-25"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01842-25","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,23]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01842-25"}}