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Several promising vaccine delivery tools have been developed, and immunogen optimization is now crucial for effective T-cell induction. Conventional immunogens have been designed to induce virus-specific CD4\n            <jats:sup>+<\/jats:sup>\n            T cells as well as CD8\n            <jats:sup>+<\/jats:sup>\n            T cells, but induction of virus-specific CD4\n            <jats:sup>+<\/jats:sup>\n            T cells that are preferential targets for HIV infection could enhance acute HIV proliferation. Here, we designed a novel immunogen to induce HIV-specific CD8\n            <jats:sup>+<\/jats:sup>\n            T cells without HIV-specific CD4\n            <jats:sup>+<\/jats:sup>\n            T-cell induction but with non-HIV antigen-specific CD4\n            <jats:sup>+<\/jats:sup>\n            T-cell help. Our analysis in a macaque AIDS model showed that our immunogen can efficiently elicit effective CD8\n            <jats:sup>+<\/jats:sup>\n            T but not CD4\n            <jats:sup>+<\/jats:sup>\n            T cells targeting viral antigens, resulting in no enhancement of acute viral replication after virus exposure. This immunogen design, also applicable for other currently developed immunogens, could be a promising method for selective induction of effective anti-HIV CD8\n            <jats:sup>+<\/jats:sup>\n            T-cell responses.\n          <\/jats:p>","DOI":"10.1128\/jvi.01876-19","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T10:06:19Z","timestamp":1580465179000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["A Novel Immunogen Selectively Eliciting CD8\n            <sup>+<\/sup>\n            T Cells but Not CD4\n            <sup>+<\/sup>\n            T Cells Targeting Immunodeficiency Virus Antigens"],"prefix":"10.1128","volume":"94","author":[{"given":"Hiroshi","family":"Ishii","sequence":"first","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Terahara","sequence":"additional","affiliation":[{"name":"Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takushi","family":"Nomura","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takeda","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Okazaki","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Tokusumi","sequence":"additional","affiliation":[{"name":"ID Pharma Co., Ltd., Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsugumine","family":"Shu","sequence":"additional","affiliation":[{"name":"ID Pharma Co., Ltd., Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Matano","sequence":"additional","affiliation":[{"name":"AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan"},{"name":"Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"UNAIDS. 2019. 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Guidelines for proper conduct of animal experiments. http:\/\/www.scj.go.jp\/ja\/info\/kohyo\/pdf\/kohyo-20-k16-2e.pdf."},{"key":"e_1_3_2_41_2","unstructured":"Weatherall D (ed). 2006. The use of non-human primates in research. https:\/\/royalsociety.org\/topics-policy\/publications\/2006\/weatherall-report\/."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep30153"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00557-16"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01876-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.01876-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T15:03:57Z","timestamp":1646492637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.01876-19"}},"subtitle":[],"editor":[{"given":"Guido","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,3,31]]}},"alternative-id":["10.1128\/JVI.01876-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.01876-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,31]]},"assertion":[{"value":"2019-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01876-19"}}