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Moreover, infection of immune cells by VZV results in attenuation of the antiviral mechanisms used to control infection and limit spread. Here, we provide evidence that human monocytes, which are highly abundant in the circulation, are permissive to productive VZV infection. Furthermore, monocyte-derived macrophages were also highly permissive to VZV infection, although VZV-infected monocytes were unable to differentiate into macrophages. Exploring the relationships between VZV and permissive immune cells, such as human monocytes and macrophages, elucidates novel immune evasion strategies and provides further insight into the control that VZV has over the immune system.<\/jats:p>","DOI":"10.1128\/jvi.01887-18","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T11:06:54Z","timestamp":1541675214000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Infection and Functional Modulation of Human Monocytes and Macrophages by Varicella-Zoster Virus"],"prefix":"10.1128","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-4890","authenticated-orcid":false,"given":"Jarrod J.","family":"Kennedy","sequence":"first","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-4204","authenticated-orcid":false,"given":"Megan","family":"Steain","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Slobedman","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Abendroth","sequence":"additional","affiliation":[{"name":"Discipline of Infectious Diseases and Immunology, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Fields virology","author":"Arvin A","year":"2001","unstructured":"Arvin A. 2001. 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