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We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.<\/jats:p>","DOI":"10.1128\/jvi.01898-13","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T02:23:49Z","timestamp":1378952629000},"page":"12499-12503","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":90,"title":["Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation"],"prefix":"10.1128","volume":"87","author":[{"given":"Qiming","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California, 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