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Evidence that lytic replication, the process that leads to new virus progeny, is linked to cancer development is accumulating. Indeed, viruses such as M81 that were isolated from Far Eastern nasopharyngeal carcinomas replicate strongly in B cells. We show here that some viruses isolated from Western patients, including the MSHJ strain, share this property. Moreover, replication of both M81 and of MSHJ was sensitive to ibrutinib, a commonly used drug, thereby opening an opportunity for therapeutic intervention. Sequencing of MSHJ showed that this virus is quite distant from M81 and is much closer to nonreplicating Western viruses. We conclude that Western EBV strains are heterogeneous, with some viruses being able to replicate more strongly and therefore being potentially more pathogenic than others, and that the virus sequence information alone cannot predict this property.<\/jats:p>","DOI":"10.1128\/jvi.01918-19","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T12:59:41Z","timestamp":1582635581000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Identification and Cloning of a New Western Epstein-Barr Virus Strain That Efficiently Replicates in Primary B Cells"],"prefix":"10.1128","volume":"94","author":[{"given":"Susanne","family":"Delecluse","sequence":"first","affiliation":[{"name":"German Cancer Research Centre (DKFZ), Unit F100, Heidelberg, Germany"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit U1074, Heidelberg, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"},{"name":"Nierenzentrum Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Poirey","sequence":"additional","affiliation":[{"name":"German Cancer Research Centre (DKFZ), Unit F100, Heidelberg, Germany"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit U1074, Heidelberg, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zeier","sequence":"additional","affiliation":[{"name":"Nierenzentrum Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Behrends","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"},{"name":"Children\u2019s Hospital Schwabing, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Research Unit Gene Vectors, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Han","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri-Jacques","family":"Delecluse","sequence":"additional","affiliation":[{"name":"German Cancer Research Centre (DKFZ), Unit F100, Heidelberg, Germany"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit U1074, Heidelberg, Germany"},{"name":"German Center for Infection Research (DZIF), Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"2655","volume-title":"Epstein-Barr virus","author":"Rickinson AB","year":"2007","unstructured":"Rickinson AB, Kieff E. 2007. 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