{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:30:38Z","timestamp":1765485038697},"reference-count":47,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ectromelia virus (ECTV), a natural mouse pathogen and the causative agent of mousepox, is closely related to variola virus (VARV), which causes smallpox in humans. Mousepox is an excellent surrogate small-animal model for smallpox. Both ECTV and VARV encode a multitude of host response modifiers that target components of the immune system and that are thought to contribute to the high mortality rates associated with infection. Like VARV, ECTV encodes a protein homologous to the ectodomain of the host gamma interferon (IFN-\u03b3) receptor 1. We generated an IFN-\u03b3 binding protein (IFN-\u03b3bp) deletion mutant of ECTV to study the role of viral IFN-\u03b3bp (vIFN-\u03b3bp) in host-virus interaction and also to elucidate the contribution of this molecule to the outcome of infection. Our data show that the absence of vIFN-\u03b3bp does not affect virus replication per se but does have a profound effect on virus replication and pathogenesis in mice. BALB\/c mice, which are normally susceptible to infection with ECTV, were able to control replication of the mutant virus and survive infection. Absence of vIFN-\u03b3bp from ECTV allowed the generation of an effective host immune response that was otherwise diminished by this viral protein. Mice infected with a vIFN-\u03b3bp deletion mutant virus, designated ECTV-IFN-\u03b3bp<jats:sup>\u0394<\/jats:sup>, produced increased levels of IFN-\u03b3 and generated robust cell-mediated and antibody responses. Using several strains of mice that exhibit differential degrees of resistance to mousepox, we show that recovery or death from ECTV infection is determined by a balance between the host's ability to produce IFN-\u03b3 and the virus' ability to dampen its effects.<\/jats:p>","DOI":"10.1128\/jvi.01927-06","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T01:34:42Z","timestamp":1169084082000},"page":"3346-3353","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Poxvirus-Encoded Gamma Interferon Binding Protein Dampens the Host Immune Response to Infection"],"prefix":"10.1128","volume":"81","author":[{"given":"Isaac G.","family":"Sakala","sequence":"first","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geeta","family":"Chaudhri","sequence":"additional","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Mark","family":"Buller","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, Saint Louis, Missouri 63104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Nuara","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, Saint Louis, Missouri 63104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongdong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, Saint Louis, Missouri 63104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanhai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, 1402 South Grand Boulevard, Saint Louis, Missouri 63104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunasegaran","family":"Karupiah","sequence":"additional","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.01.015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-5-1159"},{"key":"e_1_3_2_4_2","first-page":"125","year":"1989","unstructured":"Blanden, R. 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