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In clade C, the C3 region \u03b12-helix exhibits high sequence entropy at the polar face but maintains its amphipathicity, whereas in clade B it accommodates hydrophobic residues. The V4 hypervariable domain in clade C is shorter than that in clade B. Generally, shorter V4 loops are incompatible with a glycine occurring in the \u03b12-helix in clade C, an intriguing association that could be exploited to inform Env immunogen design.<\/jats:p>","DOI":"10.1128\/jvi.01954-06","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T02:53:03Z","timestamp":1166064783000},"page":"4886-4891","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":59,"title":["Clade-Specific Differences between Human Immunodeficiency Virus Type 1 Clades B and C: Diversity and Correlations in C3-V4 Regions of gp120"],"prefix":"10.1128","volume":"81","author":[{"given":"S.","family":"Gnanakaran","sequence":"first","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Lang","sequence":"additional","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Daniels","sequence":"additional","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanmoy","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545"},{"name":"Santa Fe Institute, Santa Fe, New Mexico 87501"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia A.","family":"Derdeyn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine"},{"name":"Yerkes National Primate Research Center"},{"name":"Emory Vaccine Center, Emory University, Atlanta, Georgia 30329"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bette","family":"Korber","sequence":"additional","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545"},{"name":"Santa Fe Institute, Santa Fe, New Mexico 87501"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131528"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.10.6528-6531.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.4.1962-1970.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00124a002"},{"key":"e_1_3_2_6_2","first-page":"2019","volume":"26","year":"2004","unstructured":"Derdeyn, C. 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