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Here, we report that the HSV-1 large tegument protein, VP1\/2, interacts with and regulates the ubiquitination of Tsg101, a cellular protein essential in MVB formation, thus identifying the first cellular substrate of a herpesviral deubiquitinating enzyme.<\/jats:p>","DOI":"10.1128\/jvi.01969-12","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T14:11:10Z","timestamp":1350569470000},"page":"692-696","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Tsg101 Interacts with Herpes Simplex Virus 1 VP1\/2 and Is a Substrate of VP1\/2 Ubiquitin-Specific Protease Domain Activity"],"prefix":"10.1128","volume":"87","author":[{"given":"Martina","family":"Caduco","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, University of Padova, Padova, 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