{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:17:13Z","timestamp":1791429433626,"version":"4.3.3"},"reference-count":57,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI123718"],"award-info":[{"award-number":["R21 AI123718"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:p>Hepatitis delta virus (HDV) is a satellite of hepatitis B virus that increases the severity of liver disease; approximately 15 million people are chronically infected worldwide. There are no licensed therapies available. HDV is not related to any known virus, and few details regarding its replication cycle are known. One key question is whether and how HDV regulates the relative amounts of viral RNA and protein in infected cells. Such regulation might be important because the HDV RNA and protein form complexes that are essential for HDV replication, and the proper stoichiometry of these complexes could be critical for their function. Our results show that the relative amounts of HDV RNA and protein in cells are indeed important for HDV replication and that the virus does control them. These observations indicate that further study of these regulatory mechanisms is required to better understand replication of this serious human pathogen.<\/jats:p>","DOI":"10.1128\/jvi.01989-18","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T13:47:26Z","timestamp":1549374446000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis Delta Antigen Regulates mRNA and Antigenome RNA Levels during Hepatitis Delta Virus Replication"],"prefix":"10.1128","volume":"93","author":[{"given":"Kaneemozhe","family":"Harichandran","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Stephenson Tsoris","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See-Chi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001150"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/323558a0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01758-07"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02083-09"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.15"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/v1030818"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.12.4439-4444.1988"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.62.8.2674-2679.1988"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.6.1831"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.424"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9364"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.16.7204-7210.2000"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.9.5807-5811.1996"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.5.2672-2680.1993"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.4.2221-2227.1993"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.8.3709-3719.2002"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8182-8188.2005"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.12.6438-6446.1991"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.5449-5456.1998"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.9.4517-4524.2004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.1.157"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.7164905"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838299991033"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.10.4292-4297.1989"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.64.10.5066-5069.1990"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.11.5737-5744.2004"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/v2010131"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00245-06"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.19.9016"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.5.1945-1950.1989"},{"key":"e_1_3_2_33_2","first-page":"293","article-title":"Replication of monomeric genomic delta RNA in cultured cells","volume":"364","author":"Glenn JS","year":"1991","unstructured":"Glenn JS, Taylor J, White JM. 1991. 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