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There are upwards of 300 of these genes, the majority of which do not have a clearly defined function or mechanism of action. The cellular location of these proteins may have an important effect on their function. One ISG located at the plasma membrane is interferon-inducible transmembrane protein 1 (IFITM1). Here we demonstrate that IFITM1 can inhibit infection with a range of viruses that enter via the plasma membrane. Mutant IFITM1 proteins that were unable to localize to the plasma membrane did not restrict viral infection. We also observed for the first time that IFITM1 plays a role\n                    <jats:italic>in vivo<\/jats:italic>\n                    , and\n                    <jats:italic>\n                      Ifitm1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice were more susceptible to viral lung infection. These data contribute to our understanding of how ISGs prevent viral infections.\n                  <\/jats:p>","DOI":"10.1128\/jvi.02003-18","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T06:12:37Z","timestamp":1545286357000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":81,"title":["Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane"],"prefix":"10.1128","volume":"93","author":[{"given":"S. E.","family":"Smith","sequence":"first","affiliation":[{"name":"Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom"},{"name":"Kymab Ltd., Babraham Research Campus, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3872-3557","authenticated-orcid":false,"given":"D. 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