{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:12:37Z","timestamp":1780344757537,"version":"3.54.1"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"HHS | NIH | National Eye Institute","award":["RO1EY026944, RO1EY029160, RO1EY013615, RO1EY033574"],"award-info":[{"award-number":["RO1EY026944, RO1EY029160, RO1EY013615, RO1EY033574"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2024,3,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Herpes simplex virus-1 (HSV-1) infections are among the most frequent serious viral eye infections in the U.S. and are a major cause of viral-induced blindness. HSV-1 infection is known to induce T cell activation, proliferation, and differentiation that play crucial roles in the development of virus-induced inflammatory lesions, leading to eye disease and causing chronic corneal damage. CD80 is a co-stimulatory molecule and plays a leading role in T cell differentiation. Previous efforts to limit lesion severity by controlling inflammation at the cellular level led us to ask whether mice knocked out for CD80 would show attenuated virus replication following reactivation. By evaluating the effects of CD80 activity on primary and latent infection, we found that in the absence of CD80, virus replication in the eyes and virus reactivation in latent trigeminal ganglia were both significantly reduced. However, latency in latently infected CD80\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice did not differ significantly from that in wild-type (WT) control mice. Reduced virus replication in the eyes of CD80\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice correlated with significantly expanded CD11c gene expression as compared to WT mice. Taken together, our results indicate that suppression of CD80 could offer significant beneficial therapeutic effects in the treatment of Herpes Stromal Keratitis (HSK).\n            <\/jats:p>\n            <jats:sec>\n              <jats:title>IMPORTANCE<\/jats:title>\n              <jats:p>Of the many problems associated with recurrent ocular infection, reducing virus reactivation should be a major goal of controlling ocular herpes simplex virus-1 (HSV-1) infection. In this study, we have shown that the absence of CD80 reduces HSV-1 reactivation, which marks the establishment of a previously undescribed mechanism underlying viral immune evasion that could be exploited to better manage HSV infection.<\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/jvi.02010-23","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T14:02:02Z","timestamp":1708437722000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels"],"prefix":"10.1128","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-659X","authenticated-orcid":false,"given":"Ujjaldeep","family":"Jaggi","sequence":"first","affiliation":[{"name":"Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry H.","family":"Matundan","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-9685","authenticated-orcid":false,"given":"Jay J.","family":"Oh","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-1995","authenticated-orcid":false,"given":"Homayon","family":"Ghiasi","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3665"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1982373"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155654"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/612316"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.03.003"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820530802111085"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.03.003"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.3.1383"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.63.2.769-775.1989"},{"key":"e_1_3_5_11_2","first-page":"366","article-title":"Effects of CD4+ and CD8+ T-lymphocyte depletion on the induction and expression of herpes Simplex Stromal Keratitis","volume":"2","author":"Newell CK","year":"1989","unstructured":"Newell CK, Sendele D, Rouse BT. 1989. Effects of CD4+ and CD8+ T-lymphocyte depletion on the induction and expression of herpes Simplex Stromal Keratitis. Reg Immunol 2:366\u2013369.","journal-title":"Reg Immunol"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.233"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1615\/critrevimmunol.v18.i5.10"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri727"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.1.185"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01803-18"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01036-21"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00700-20"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27701"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80333-7"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.11.003"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12823"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02290-10"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087617"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.6.20"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009999"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008971"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215727"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-69-12-3101"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.03.002"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(13)31155-5"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.11.969"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200101000-00001"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199903000-00001"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.4.2118-2126.1994"},{"key":"e_1_3_5_36_2","first-page":"1352","article-title":"Protection against herpes simplex virus-induced eye disease after vaccination with seven individually expressed herpes simplex virus 1 glycoproteins","volume":"36","author":"Ghiasi H","year":"1995","unstructured":"Ghiasi H, Bahri S, Nesburn AB, Wechsler SL. 1995. Protection against herpes simplex virus-induced eye disease after vaccination with seven individually expressed herpes simplex virus 1 glycoproteins. Invest Ophthalmol Vis Sci 36:1352\u20131360.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273940490518775"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01798-19"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01511-19"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00255-16"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2018.04.007"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01442-07"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.02010-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.02010-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T18:26:01Z","timestamp":1726511161000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.02010-23"}},"subtitle":[],"editor":[{"given":"Lori","family":"Frappier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,19]]}},"alternative-id":["10.1128\/jvi.02010-23"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02010-23","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"assertion":[{"value":"2023-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02010-23"}}