{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:05:31Z","timestamp":1789628731966,"version":"build-2803163510"},"reference-count":63,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T00:00:00Z","timestamp":1271289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Monkeypox virus (MPXV) is an orthopoxvirus closely related to variola, the etiological agent of smallpox. In humans, MPXV causes a disease similar to smallpox and is considered to be an emerging infectious disease. Moreover, the use of MPXV for bioterroristic\/biowarfare activities is of significant concern. Available small animal models of human monkeypox have been restricted to mammals with poorly defined biologies that also have limited reagent availability. We have established a murine MPXV model utilizing the STAT1-deficient C57BL\/6 mouse. Here we report that a relatively low-dose intranasal (IN) infection induces 100% mortality in the\n            <jats:italic>stat1<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            model by day 10 postinfection with high infectious titers in the livers, spleens, and lungs of moribund animals. Vaccination with modified vaccinia virus Ankara (MVA) followed by a booster vaccination is sufficient to protect against an intranasal MPXV challenge and induces an immune response more robust than that of a single vaccination. Furthermore, antiviral treatment with CMX001 (HDP-cidofovir) and ST-246 protects when administered as a regimen initiated on the day of infection. Thus, the\n            <jats:italic>stat1<\/jats:italic>\n            <jats:sup>\u2212<\/jats:sup>\n            <jats:sup>\/<\/jats:sup>\n            <jats:sup>\u2212<\/jats:sup>\n            model provides a lethal murine platform for evaluating therapeutics and for investigating the immunological and pathological responses to MPXV infection.\n          <\/jats:p>","DOI":"10.1128\/jvi.02012-09","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T01:55:52Z","timestamp":1265248552000},"page":"3909-3920","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":108,"title":["A Mouse Model of Lethal Infection for Evaluating Prophylactics and Therapeutics against Monkeypox Virus"],"prefix":"10.1128","volume":"84","author":[{"given":"Jennifer","family":"Stabenow","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Mark","family":"Buller","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Schriewer","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheri","family":"West","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Saint Louis University Medical School, 1100 S. Grand Blvd., St Louis, Missouri 63104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Sagartz","sequence":"additional","affiliation":[{"name":"Seventh Wave Laboratories, LLC, 743 Sprint 40 Park Drive, Suite 209, Chesterfield, Missouri 63005"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.749"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.01.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.11.015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020131"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.5078"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.05.030"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.27.15974"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061154"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81289-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81090-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.11.8550-8558.1998"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.3.1257-1264.2004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1003.030878"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.20.11416-11421.2004"},{"key":"e_1_3_2_17_2","first-page":"221","year":"1995","unstructured":"Hoogland, J. 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