{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T05:00:00Z","timestamp":1789275600401,"version":"build-2803163510"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Human T-lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). In Japan, the number of HTLV-1 carriers is estimated to be 1.2 million and more than 700 cases of ATL have been diagnosed every year. Considering the poor prognosis and lack of curative therapy of ATL, it seems mandatory to establish an effective strategy for the treatment of ATL. In this study, we attempted to identify the cell surface molecules that will become suitable targets of antibodies for anti-ATL therapy. The expression levels of approximately 40,000 host genes of three human T-cell lines carrying HTLV-1 genomes were analyzed by oligonucleotide microarray and compared with the expression levels of the genes in an HTLV-1-negative T-cell line. The HTLV-1-carrying T-cell lines used for experiments had totally different expression patterns of viral genome. Among the genes evaluated, the expression levels of 108 genes were found to be enhanced more than 10-fold in all of the T-cell lines examined and 11 of the 108 genes were considered to generate the proteins expressed on the cell surface. In particular, the CD70 gene was upregulated more than 1,000-fold and the enhanced expression of the CD70 molecule was confirmed by laser flow cytometry for various HTLV-1-carrying T-cell lines and primary CD4<jats:sup>+<\/jats:sup>T cells isolated from acute-type ATL patients. Such expression was not observed for primary CD4<jats:sup>+<\/jats:sup>T cells isolated from healthy donors. Since CD70 expression is strictly restricted in normal tissues, such as highly activated T and B cells, CD70 appears to be a potential target for effective antibody therapy against ATL.<\/jats:p>","DOI":"10.1128\/jvi.02013-07","type":"journal-article","created":{"date-parts":[[2008,2,7]],"date-time":"2008-02-07T01:45:27Z","timestamp":1202348727000},"page":"3843-3852","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Highly Enhanced Expression of CD70 on Human T-Lymphotropic Virus Type 1-Carrying T-Cell Lines and Adult T-Cell Leukemia Cells"],"prefix":"10.1128","volume":"82","author":[{"given":"Masanori","family":"Baba","sequence":"first","affiliation":[{"name":"Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Horai","sequence":"additional","affiliation":[{"name":"Division of Host Response, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Kagoshima University, Kagoshima 890-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Suda","sequence":"additional","affiliation":[{"name":"Nanostructured and Advanced Materials Course, Graduate School of Science and Engineering, Kagoshima University, Kagoshima 890-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomichi","family":"Arima","sequence":"additional","affiliation":[{"name":"Division of Host Response, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1645","volume":"12","year":"1996","unstructured":"Akagi, T., H. Ono, and K. Shimotohno. 1996. Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18(Ink4) and p21(Waf1\/Cip1\/Sdi1). Oncogene12:1645-1652.","journal-title":"Oncogene"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.12.6892-6899.1991"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb04531.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.04.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199600001-00013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4395"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209898"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/08892220050193164"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202405"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01467-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.5.3258-3263.1996"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4049\/jimmunol.161.6.3087","volume":"161","year":"1998","unstructured":"Hasegawa, H., T. Nomura, K. Kishimoto, K. Yanagisawa, and S. Fujita. 1998. SFA-1\/PETA-3 (CD151), a member of the transmembrane 4 superfamily, associates preferentially with \u03b15\u03b21 integrin and regulates adhesion of human T cell leukemia virus type 1-infected T cells to fibronectin. J. Immunol.161:3087-3095.","journal-title":"J. Immunol."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-6192-2"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983554"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000158121.49085.ba"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01974.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2883"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1158\/1078-0432.129.11.1","volume":"11","year":"2005","unstructured":"Lin, M. Z., M. A. Teitell, and G. J. Schiller. 2005. The evolution of antibodies into versatile tumor-targeting agents. Clin. Cancer Res.11:129-138.","journal-title":"Clin. Cancer Res."},{"key":"e_1_3_2_22_2","first-page":"5","volume":"67","year":"2007","unstructured":"Marcus, R., and A. Hagenbeek. 2007. The therapeutic use of rituximab in non-Hodgkin's lymphoma. Eur. J. Haematol. S.67:5-14.","journal-title":"Eur. J. Haematol. S."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034017"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-1-39"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011158021749"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2005.21.273"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204513"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.1.275"},{"key":"e_1_3_2_30_2","first-page":"10310","volume":"1","year":"1986","unstructured":"Osame, M., K. Usuku, S. Izumo, N. Ijichi, H. Amitani, A. Igata, M. Matsumoto, and M. Tara. 1986. HTLV-I associated myelopathy, a new clinical entity. Lancet1:10310-11032.","journal-title":"Lancet"},{"key":"e_1_3_2_31_2","first-page":"3562","volume":"62","year":"2002","unstructured":"Pise-Masison, C. A., M. Radonovich, R. Mahieux, P. Chatterjee, C. Whiteford, J. Duvall, C. Guillerm, A. Gessain, and J. N. Brady. 2002. Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes. Cancer Res.62:3562-3571.","journal-title":"Cancer Res."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208968"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.2.435.435"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1150"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(83)90395-1"},{"key":"e_1_3_2_36_2","first-page":"1204","volume":"105","year":"2005","unstructured":"Sasaki, H., I. Nishikata, T. Shiraga, E. Akamatsu, T. Fukami, T. Hidaka, Y. Kubuki, A. Okayama, K. Hamada, H. Okabe, Y. Murakami, H. Tsubouchi, and K. Morishita. 2005. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood105:1204-1213.","journal-title":"Blood"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215549704500404"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-16"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02554.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208979"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.6.1359"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4782"},{"key":"e_1_3_2_44_2","first-page":"2592","volume":"62","year":"2002","unstructured":"Wischhusen, J., G. Jung, I. Radovanovic, C. Beier, J. P. Steinbach, A. Rimner, H. Huang, J. B. Schulz, H. Ohgaki, A. Aguzzi, H. G. Rammensee, and M. Weller. 2002. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer Res.62:2592-2599.","journal-title":"Cancer Res."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5978-5988.2004"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02013-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02013-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:29:45Z","timestamp":1684236585000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02013-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,15]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,4,15]]}},"alternative-id":["10.1128\/JVI.02013-07"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02013-07","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,15]]},"assertion":[{"value":"2007-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}