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We showed that in infected cells, L* is partitioned between the cytosol and the mitochondria. In mitochondria, L* is anchored in the outer membrane and exposed to the cytosol. The targeting of L* to mitochondria is independent of other viral components and likely depends on a conformational signal. L* targeting to mitochondria might involve chaperones of the Hsp70 family, as these proteins are shown to interact.<\/jats:p>","DOI":"10.1128\/jvi.02023-10","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T03:48:51Z","timestamp":1294890531000},"page":"3690-3694","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Theiler's Virus L* Protein Is Targeted to the Mitochondrial Outer Membrane"],"prefix":"10.1128","volume":"85","author":[{"given":"Fre\u0301de\u0301ric","family":"Sorgeloos","sequence":"first","affiliation":[{"name":"Universite\u0301 Catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, 74 Avenue Hippocrate, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Vertommen","sequence":"additional","affiliation":[{"name":"Universite\u0301 Catholique de Louvain, de Duve Institute, HORM-PHOS 75-29, 75 Avenue Hippocrate, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Rider","sequence":"additional","affiliation":[{"name":"Universite\u0301 Catholique de Louvain, de Duve Institute, HORM-PHOS 75-29, 75 Avenue Hippocrate, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Michiels","sequence":"additional","affiliation":[{"name":"Universite\u0301 Catholique de Louvain, de Duve Institute, MIPA-VIRO 74-49, 74 Avenue Hippocrate, B-1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.002410"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82381-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.59.030804.121242"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0995-927"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.095505"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.93.1.97"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.11.8605-8612.1998"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.4049\/jimmunol.163.9.4683","volume":"163","year":"1999","unstructured":"Heibein, J. 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