{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:50:58Z","timestamp":1773089458993,"version":"3.50.1"},"reference-count":59,"publisher":"American Society for Microbiology","issue":"13","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000098","name":"HHS | NIH | NIH Clinical Center","doi-asserted-by":"publisher","award":["RO1 AI133673"],"award-info":[{"award-number":["RO1 AI133673"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT104748MA"],"award-info":[{"award-number":["WT104748MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2020,6,16]]},"abstract":"<jats:p>Few studies have addressed the mechanisms of immune control in HIV-infected subjects in India, where an estimated 2.7 million people are living with HIV. We focus here on a study cohort in Delhi on one of the most prevalent HLA-B alleles, HLA-B*52:01, present in 22.5% of infected individuals. HLA-B*52:01 has consistently been shown in other cohorts to be associated with protection against HIV disease progression, but studies have been limited by the low prevalence of this allele in North America and Europe. Among the C-clade-infected individuals, we show that HLA-B*52:01 is the most protective of all the HLA-B alleles expressed in the Indian cohort and is associated with the highest absolute CD4 counts. Further, we show that the mechanism by which HLA-B*52:01 mediates immune protection is, at least in part, related to the inability of HIV to evade the HLA-B*52:01-restricted p24 Gag-specific CD8<jats:sup>+<\/jats:sup>T-cell response without incurring a significant loss to viral replicative capacity.<\/jats:p>","DOI":"10.1128\/jvi.02025-19","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T15:07:32Z","timestamp":1587395252000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Impact of HLA-B*52:01-Driven Escape Mutations on Viral Replicative Capacity"],"prefix":"10.1128","volume":"94","author":[{"given":"Ming-Han Chloe","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, National Centre for Disease Control, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Adland","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Goulder","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-062909-130018"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03113"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195271"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06407.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328360a4bd"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2006.02.002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.14"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02572-12"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00147-14"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-015-0223-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00020-15"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13337-010-0001-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.4049\/jimmunol.154.8.4174","article-title":"CTLs from lymphoid organs recognize an optimal HLA-A2-restricted and HLA-B52-restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef","volume":"154","author":"Hadida F","year":"1995","unstructured":"Hadida F, Haas G, Zimmermann N, Hosmalin A, Spohn R, Samri A, Jung G, Debre P, Autran B. 1995. CTLs from lymphoid organs recognize an optimal HLA-A2-restricted and HLA-B52-restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef. J Immunol 154:4174\u20134186.","journal-title":"J Immunol"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.12.10191-10198.1999"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01041-08"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01998-12"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00579-09"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07746"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.7.3617-3623.2006"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00665"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072457"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003041"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00465-07"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06682-11"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-016-0300-y"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003711"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32251"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442203"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000322"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4100"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004954"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm998"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm992"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.17.11529-11532.2005"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00968-06"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031982"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.10.010"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8171-8181.2005"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2013.08.002"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01004-14"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232685"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00689-12"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2035"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.075"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix483"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01749-17"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02142-18"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12309"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39157"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3445-0"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.4238\/2015.November.18.58"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.4238\/2012.February.3.2"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.03.017"},{"key":"e_1_3_2_56_2","first-page":"S10","article-title":"HLA-B genotype in Japanese patients with Crohn\u2019s disease","volume":"46","author":"Kinouchi Y","year":"2003","unstructured":"Kinouchi Y, Matsumoto K, Negoro K, Takagi S, Takahashi S, Hiwatashi N, Shimosegawa T. 2003. HLA-B genotype in Japanese patients with Crohn\u2019s disease. Dis Colon Rectum 46(10 Suppl):S10\u2013S14.","journal-title":"Dis Colon Rectum"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600405.x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.01.014"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01369-07"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01084-10"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02025-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JVI.02025-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T04:08:47Z","timestamp":1696046927000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JVI.02025-19"}},"subtitle":[],"editor":[{"given":"Guido","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":59,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,6,16]]}},"alternative-id":["10.1128\/JVI.02025-19"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02025-19","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"2020-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02025-19"}}