{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:49:48Z","timestamp":1771660188380,"version":"3.50.1"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/I\/00007032"],"award-info":[{"award-number":["BBS\/E\/I\/00007032"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/I\/00007039"],"award-info":[{"award-number":["BBS\/E\/I\/00007039"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R007896\/1"],"award-info":[{"award-number":["BB\/R007896\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/OS\/NW\/000007"],"award-info":[{"award-number":["BBS\/OS\/NW\/000007"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"UKRI | Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R007632\/1"],"award-info":[{"award-number":["BB\/R007632\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2022,3,23]]},"abstract":"<jats:p>Marek\u2019s disease (MD) is a lymphoproliferative disease of chickens characterized by rapid-onset lymphomas in multiple organs and by infiltration into peripheral nerves, causing paralysis. Lymphoblastoid cell lines (LCL) derived from MD lymphomas have served as valuable resources to improve understanding of distinct aspects of virus-host interactions in transformed cells including transformation, latency, and reactivation.<\/jats:p>","DOI":"10.1128\/jvi.02027-21","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T16:28:51Z","timestamp":1643819331000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Targeted Deletion of Glycoprotein B Gene by CRISPR\/Cas9 Nuclease Inhibits\n            <i>Gallid herpesvirus<\/i>\n            Type 3 in Dually Infected Marek\u2019s Disease Virus-Transformed Lymphoblastoid Cell Line MSB-1"],"prefix":"10.1128","volume":"96","author":[{"given":"Yaoyao","family":"Zhang","sequence":"first","affiliation":[{"name":"The Pirbright Institute, Pirbright, Guildford, Surrey, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weicheng","family":"Li","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Pirbright, Guildford, Surrey, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Tang","sequence":"additional","affiliation":[{"name":"Shandong Binzhou Animal Science and Veterinary Medicine Academy &amp; UK-China Centre of Excellence for Research on Avian Diseases, Binzhou, Shandong, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katy","family":"Moffat","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Pirbright, Guildford, Surrey, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venugopal","family":"Nair","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Pirbright, Guildford, Surrey, United Kingdom"},{"name":"The Jenner Institute Laboratories, University of Oxford, Oxford, United Kingdom"},{"name":"Department of Zoology, University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-3949","authenticated-orcid":true,"given":"Yongxiu","family":"Yao","sequence":"additional","affiliation":[{"name":"The Pirbright Institute, Pirbright, Guildford, Surrey, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-008-0278-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408418509104432"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1382"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020116"},{"key":"e_1_3_2_6_2","first-page":"57","article-title":"Protective efficacy of Marek\u2019s disease vaccines","volume":"255","author":"Witter RL","year":"2001","unstructured":"Witter RL. 2001. Protective efficacy of Marek\u2019s disease vaccines. Curr Top Microbiol Immunol 255:57\u201390.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2307\/1590330"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12180"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004090"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.05.002"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-015-1796-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep19176"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.08.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.09.004"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00339-15"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000012"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00139-16"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01554-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.12.025"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8010097"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/v11050391"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00713-19"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/v10060279"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005701"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02183-18"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep02510"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1405186111"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7413"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.07.020"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001337"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06113-11"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000744"},{"key":"e_1_3_2_33_2","first-page":"105","article-title":"Two cell lines from lymphomas of Marek\u2019s disease","volume":"17","author":"Akiyama Y","year":"1974","unstructured":"Akiyama Y, Kato S. 1974. Two cell lines from lymphomas of Marek\u2019s disease. Biken J 17:105\u2013116.","journal-title":"Biken J"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/54.1.277"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01310745"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00112-07"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054761"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2004.08.019"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep19675"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9170-9_1"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247005"},{"key":"e_1_3_2_42_2","first-page":"1","article-title":"Targeted editing of avian herpesvirus vaccine vector using CRISPR\/Cas9 nucleases","volume":"1","author":"Yao Y","year":"2016","unstructured":"Yao Y, Bassett A, Nair V. 2016. Targeted editing of avian herpesvirus vaccine vector using CRISPR\/Cas9 nucleases. J Vaccine & Technol 1:1\u20137.","journal-title":"J Vaccine & Technol"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67951-1"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12040466"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051215-031129"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9010164"}],"container-title":["Journal of Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.02027-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jvi.02027-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T13:08:22Z","timestamp":1648040902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.02027-21"}},"subtitle":[],"editor":[{"given":"Jae U.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,3,23]]}},"alternative-id":["10.1128\/jvi.02027-21"],"URL":"https:\/\/doi.org\/10.1128\/jvi.02027-21","relation":{},"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"assertion":[{"value":"2021-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02027-21"}}