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Joint pain, swelling, and stiffness can endure for months to years after CHIKV infection, and epidemics have a severe economic impact. Elucidating the mechanisms by which CHIKV subverts antiviral immunity to establish and maintain a persistent infection may lead to the development of new therapeutic strategies against chronic CHIKV disease. In this study, we found that CHIKV establishes and maintains a persistent infection in joint-associated tissue in part by evading antiviral CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell immunity. Thus, immunomodulatory therapies that improve CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell immune surveillance and clearance of CHIKV infection could be a strategy for mitigating chronic CHIKV disease.\n                  <\/jats:p>","DOI":"10.1128\/jvi.02036-19","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T09:45:49Z","timestamp":1582278349000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Chikungunya Virus Evades Antiviral CD8\n                    <sup>+<\/sup>\n                    T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues"],"prefix":"10.1128","volume":"94","author":[{"given":"Bennett J.","family":"Davenport","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bullock","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Hawman","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross M.","family":"Kedl","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA"},{"name":"The Andrew M. and Jane M. 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