{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:49:59Z","timestamp":1791067799853,"version":"4.1.0"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T00:00:00Z","timestamp":1271289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Virol"],"published-print":{"date-parts":[[2010,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Murine gammaherpesvirus 68 (MHV-68) infection of laboratory mice (\n            <jats:italic>Mus musculus<\/jats:italic>\n            ) is an established model of gammaherpesvirus pathogenesis. The fact that\n            <jats:italic>M. musculus<\/jats:italic>\n            is not a host in the wild prompted us to reassess MHV-68 infection in wood mice (\n            <jats:italic>Apodemus sylvaticus<\/jats:italic>\n            ), a natural host. Here, we report significant differences in MHV-68 infection in the two species: (i) following intranasal inoculation, MHV-68 replicated in the lungs of wood mice to levels approximately 3 log units lower than in BALB\/c mice; (ii) in BALB\/c mice, virus replication in alveolar epithelial cells was accompanied by a diffuse, T-cell-dominated interstitial pneumonitis, whereas in wood mice it was restricted to focal granulomatous infiltrations; (iii) within wood mice, latently infected lymphocytes were abundant in inducible bronchus-associated lymphoid tissue that was not apparent in BALB\/c mice; (iv) splenic latency was established in both species, but well-delineated secondary follicles with germinal centers were present in wood mice, while only poorly delineated follicles were seen in BALB\/c mice; and, perhaps as a consequence, (v) production of neutralizing antibody was significantly higher in wood mice. These differences highlight the value of this animal model in the study of MHV-68 pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/jvi.02085-09","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T01:55:52Z","timestamp":1265248552000},"page":"3949-3961","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Pathogenesis of a Model Gammaherpesvirus in a Natural Host"],"prefix":"10.1128","volume":"84","author":[{"given":"David J.","family":"Hughes","sequence":"first","affiliation":[{"name":"School of Infection and Host Defence"},{"name":"Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Kipar","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, University of Liverpool, Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery T.","family":"Sample","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Stewart","sequence":"additional","affiliation":[{"name":"School of Infection and Host Defence"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367707780378203"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(97)80041-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18731-0"},{"key":"e_1_3_2_5_2","first-page":"468","volume":"24","year":"1980","unstructured":"Blaskovic, D., M. 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